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Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice
ProBiotic-4 is a probiotic preparation composed of Bifidobacterium lactis, Lactobacillus casei, Bifidobacterium bifidum, and Lactobacillus acidophilus. This study aims to investigate the effects of ProBiotic-4 on the microbiota–gut–brain axis and cognitive deficits, and to explore the underlying mol...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049608/ https://www.ncbi.nlm.nih.gov/pubmed/32140393 http://dx.doi.org/10.1016/j.apsb.2019.07.001 |
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author | Yang, Xueqin Yu, Dongke Xue, Li Li, Hui Du, Junrong |
author_facet | Yang, Xueqin Yu, Dongke Xue, Li Li, Hui Du, Junrong |
author_sort | Yang, Xueqin |
collection | PubMed |
description | ProBiotic-4 is a probiotic preparation composed of Bifidobacterium lactis, Lactobacillus casei, Bifidobacterium bifidum, and Lactobacillus acidophilus. This study aims to investigate the effects of ProBiotic-4 on the microbiota–gut–brain axis and cognitive deficits, and to explore the underlying molecular mechanism using senescence-accelerated mouse prone 8 (SAMP8) mice. ProBiotic-4 was orally administered to 9-month-old SAMP8 mice for 12 weeks. We observed that ProBiotic-4 significantly improved the memory deficits, cerebral neuronal and synaptic injuries, glial activation, and microbiota composition in the feces and brains of aged SAMP8 mice. ProBiotic-4 substantially attenuated aging-related disruption of the intestinal barrier and blood–brain barrier, decreased interleukin-6 and tumor necrosis factor-α at both mRNA and protein levels, reduced plasma and cerebral lipopolysaccharide (LPS) concentration, toll-like receptor 4 (TLR4) expression, and nuclear factor-κB (NF-κB) nuclear translocation in the brain. In addition, not only did ProBiotic-4 significantly decreased the levels of γ-H2AX, 8-hydroxydesoxyguanosine, and retinoic-acid-inducible gene-I (RIG-I), it also abrogated RIG-I multimerization in the brain. These findings suggest that targeting gut microbiota with probiotics may have a therapeutic potential for the deficits of the microbiota–gut–brain axis and cognitive function in aging, and that its mechanism is associated with inhibition of both TLR4-and RIG-I-mediated NF-κB signaling pathway and inflammatory responses. |
format | Online Article Text |
id | pubmed-7049608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-70496082020-03-05 Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice Yang, Xueqin Yu, Dongke Xue, Li Li, Hui Du, Junrong Acta Pharm Sin B Original article ProBiotic-4 is a probiotic preparation composed of Bifidobacterium lactis, Lactobacillus casei, Bifidobacterium bifidum, and Lactobacillus acidophilus. This study aims to investigate the effects of ProBiotic-4 on the microbiota–gut–brain axis and cognitive deficits, and to explore the underlying molecular mechanism using senescence-accelerated mouse prone 8 (SAMP8) mice. ProBiotic-4 was orally administered to 9-month-old SAMP8 mice for 12 weeks. We observed that ProBiotic-4 significantly improved the memory deficits, cerebral neuronal and synaptic injuries, glial activation, and microbiota composition in the feces and brains of aged SAMP8 mice. ProBiotic-4 substantially attenuated aging-related disruption of the intestinal barrier and blood–brain barrier, decreased interleukin-6 and tumor necrosis factor-α at both mRNA and protein levels, reduced plasma and cerebral lipopolysaccharide (LPS) concentration, toll-like receptor 4 (TLR4) expression, and nuclear factor-κB (NF-κB) nuclear translocation in the brain. In addition, not only did ProBiotic-4 significantly decreased the levels of γ-H2AX, 8-hydroxydesoxyguanosine, and retinoic-acid-inducible gene-I (RIG-I), it also abrogated RIG-I multimerization in the brain. These findings suggest that targeting gut microbiota with probiotics may have a therapeutic potential for the deficits of the microbiota–gut–brain axis and cognitive function in aging, and that its mechanism is associated with inhibition of both TLR4-and RIG-I-mediated NF-κB signaling pathway and inflammatory responses. Elsevier 2020-03 2019-07-07 /pmc/articles/PMC7049608/ /pubmed/32140393 http://dx.doi.org/10.1016/j.apsb.2019.07.001 Text en © 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original article Yang, Xueqin Yu, Dongke Xue, Li Li, Hui Du, Junrong Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice |
title | Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice |
title_full | Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice |
title_fullStr | Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice |
title_full_unstemmed | Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice |
title_short | Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice |
title_sort | probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged samp8 mice |
topic | Original article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049608/ https://www.ncbi.nlm.nih.gov/pubmed/32140393 http://dx.doi.org/10.1016/j.apsb.2019.07.001 |
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