Synthesis and biological evaluation of a series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones as potential HIV-1 inhibitors

A series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones were synthesized and their anti-HIV-1 activities were evaluated. Most of these compounds were highly active against wild-type (WT) HIV-1 strain (IIIB) with EC(50) values in the range of 0.0038...

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Detalles Bibliográficos
Autores principales: Wu, Yumeng, Tang, Chengrun, Rui, Ruomei, Yang, Liumeng, Ding, Wei, Wang, Jiangyuan, Li, Yiming, Lai, Christopher C., Wang, Yueping, Luo, Ronghua, Xiao, Weilie, Zhang, Hongbing, Zheng, Yongtang, He, Yanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049619/
https://www.ncbi.nlm.nih.gov/pubmed/32140396
http://dx.doi.org/10.1016/j.apsb.2019.08.009

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