Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation

Ten-eleven translocation (Tet) enzymes are involved in DNA demethylation, important in regulating embryo development, stem cell pluripotency and tumorigenesis. Alterations of DNA methylation with age have been shown in various somatic cell types. We investigated whether Tet1 and Tet2 regulate aging....

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Detalles Bibliográficos
Autores principales: Huang, Guian, Liu, Linlin, Wang, Huasong, Gou, Mo, Gong, Peng, Tian, Chenglei, Deng, Wei, Yang, Jiao, Zhou, Tian-Tian, Xu, Guo-Liang, Liu, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049665/
https://www.ncbi.nlm.nih.gov/pubmed/32114381
http://dx.doi.org/10.1016/j.isci.2020.100908

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