The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis

Transposable elements (TEs) comprise a large proportion of long non-coding RNAs (lncRNAs). Here, we employed CRISPR to delete a short interspersed nuclear element (SINE) in Malat1, a cancer-associated lncRNA, to investigate its significance in cellular physiology. We show that Malat1 with a SINE del...

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Detalles Bibliográficos
Autores principales: Nguyen, Tuan M, Kabotyanski, Elena B, Reineke, Lucas C, Shao, Jiaofang, Xiong, Feng, Lee, Joo-Hyung, Dubrulle, Julien, Johnson, Hannah, Stossi, Fabio, Tsoi, Phoebe S, Choi, Kyoung-Jae, Ellis, Alexander G, Zhao, Na, Cao, Jin, Adewunmi, Oluwatoyosi, Ferreon, Josephine C, Ferreon, Allan Chris M, Neilson, Joel R, Mancini, Michael A, Chen, Xi, Kim, Jongchan, Ma, Li, Li, Wenbo, Rosen, Jeffrey M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049706/
https://www.ncbi.nlm.nih.gov/pubmed/31863590
http://dx.doi.org/10.1093/nar/gkz1176

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