Haplotyping by CRISPR-mediated DNA circularization (CRISPR-hapC) broadens allele-specific gene editing

Allele-specific protospacer adjacent motif (asPAM)-positioning SNPs and CRISPRs are valuable resources for gene therapy of dominant disorders. However, one technical hurdle is to identify the haplotype comprising the disease-causing allele and the distal asPAM SNPs. Here, we describe a novel CRISPR-...

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Detalles Bibliográficos
Autores principales: Yu, Jiaying, Xiang, Xi, Huang, Jinrong, Liang, Xue, Pan, Xiaoguang, Dong, Zhanying, Petersen, Trine Skov, Qu, Kunli, Yang, Ling, Zhao, Xiaoying, Li, Siyuan, Zheng, Tianyu, Xu, Zhe, Liu, Chengxun, Han, Peng, Xu, Fengping, Yang, Huanming, Liu, Xin, Zhang, Xiuqing, Bolund, Lars, Luo, Yonglun, Lin, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049710/
https://www.ncbi.nlm.nih.gov/pubmed/31943080
http://dx.doi.org/10.1093/nar/gkz1233

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