Tat IRES modulator of tat mRNA (TIM-TAM): a conserved RNA structure that controls Tat expression and acts as a switch for HIV productive and latent infection

Tat protein is essential to fully activate HIV transcription and processing of viral mRNA, and therefore determines virus expression in productive replication and the establishment and maintenance of latent infection. Here, we used thermodynamic and structure analyses to define a highly conserved se...

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Detalles Bibliográficos
Autores principales: Khoury, Georges, Mackenzie, Charlene, Ayadi, Lilia, Lewin, Sharon R, Branlant, Christiane, Purcell, Damian F J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049722/
https://www.ncbi.nlm.nih.gov/pubmed/31875221
http://dx.doi.org/10.1093/nar/gkz1181

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