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Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase

RNA aptamers that bind HIV-1 reverse transcriptase (RT) inhibit RT in enzymatic and viral replication assays. Some aptamers inhibit RT from only a few viral clades, while others show broad-spectrum inhibition. Biophysical determinants of recognition specificity are poorly understood. We investigated...

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Detalles Bibliográficos
Autores principales:	Nguyen, Phuong D M, Zheng, Jie, Gremminger, Thomas J, Qiu, Liming, Zhang, Dong, Tuske, Steve, Lange, Margaret J, Griffin, Patrick R, Arnold, Eddy, Chen, Shi-Jie, Zou, Xiaoqin, Heng, Xiao, Burke, Donald H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049723/ https://www.ncbi.nlm.nih.gov/pubmed/31943114 http://dx.doi.org/10.1093/nar/gkz1224

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