Adjacent mutations in the archaeal Rad50 ABC ATPase D-loop disrupt allosteric regulation of ATP hydrolysis through different mechanisms

DNA damage is the driving force for mutation and genomic instability, which can both lead to cell death or carcinogenesis. DNA double strand breaks are detected and processed in part by the Mre11–Rad50–Nbs1 protein complex. Although the Mre11–Rad50–Nbs1 complex is essential, several spontaneous muta...

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Detalles Bibliográficos
Autores principales: Boswell, Zachary K, Canny, Marella D, Buschmann, Tanner A, Sang, Julie, Latham, Michael P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049730/
https://www.ncbi.nlm.nih.gov/pubmed/31889185
http://dx.doi.org/10.1093/nar/gkz1228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049730/
https://www.ncbi.nlm.nih.gov/pubmed/31889185
http://dx.doi.org/10.1093/nar/gkz1228

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