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Adjacent mutations in the archaeal Rad50 ABC ATPase D-loop disrupt allosteric regulation of ATP hydrolysis through different mechanisms
DNA damage is the driving force for mutation and genomic instability, which can both lead to cell death or carcinogenesis. DNA double strand breaks are detected and processed in part by the Mre11–Rad50–Nbs1 protein complex. Although the Mre11–Rad50–Nbs1 complex is essential, several spontaneous muta...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049730/ https://www.ncbi.nlm.nih.gov/pubmed/31889185 http://dx.doi.org/10.1093/nar/gkz1228 |