Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis

[Image: see text] The orexin system, which consists of the two G protein-coupled receptors OX(1) and OX(2), activated by the neuropeptides OX-A and OX-B, is firmly established as a key regulator of behavioral arousal, sleep, and wakefulness and has been an area of intense research effort over the pa...

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Detalles Bibliográficos
Autores principales: Rappas, Mathieu, Ali, Ammar A. E., Bennett, Kirstie A., Brown, Jason D., Bucknell, Sarah J., Congreve, Miles, Cooke, Robert M., Cseke, Gabriella, de Graaf, Chris, Doré, Andrew S., Errey, James C., Jazayeri, Ali, Marshall, Fiona H., Mason, Jonathan S., Mould, Richard, Patel, Jayesh C., Tehan, Benjamin G., Weir, Malcolm, Christopher, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050010/
https://www.ncbi.nlm.nih.gov/pubmed/31860301
http://dx.doi.org/10.1021/acs.jmedchem.9b01787

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