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NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly
Virtually all eukaryotic processes are regulated by cullin-RING E3 ligase (CRL)-catalyzed protein ubiquitylation(1), which is exquisitely controlled by cullin modification with the ubiquitin (UB)-like protein NEDD8(2–6). However, how CRLs catalyze ubiquitylation, and the basis for NEDD8 activation,...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050210/ https://www.ncbi.nlm.nih.gov/pubmed/32051583 http://dx.doi.org/10.1038/s41586-020-2000-y |