Cargando…

WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism

White adipose tissue (WAT) is important for maintenance of homeostasis, because it stores energy and secretes adipokines. The WAT of obese people demonstrates mitochondrial dysfunction, accompanied by oxidative stress, which leads to insulin resistance. WW domain‐containing E3 ubiquitin protein liga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoshino, Shunsuke, Kobayashi, Masaki, Tagawa, Ryoma, Konno, Ryutaro, Abe, Takuro, Furuya, Kazuhiro, Miura, Kumi, Wakasawa, Hiroki, Okita, Naoyuki, Sudo, Yuka, Mizunoe, Yuhei, Nakagawa, Yoshimi, Nakamura, Takeshi, Kawabe, Hiroshi, Higami, Yoshikazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050250/ https://www.ncbi.nlm.nih.gov/pubmed/31965758 http://dx.doi.org/10.1002/2211-5463.12795

Ejemplares similares

Systemic depletion of WWP1 improves insulin sensitivity and lowers triglyceride content in the liver of obese mice
por: Nozaki, Yuka, et al.
Publicado: (2023)

Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes
por: Mizunoe, Yuhei, et al.
Publicado: (2020)

Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids
por: Tagawa, Ryoma, et al.
Publicado: (2022)

Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome
por: Mizunoe, Yuhei, et al.
Publicado: (2019)

Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line
por: Kobayashi, Masaki, et al.
Publicado: (2020)

Trehalose protects against oxidative stress by regulating the Keap1–Nrf2 and autophagy pathways
por: Mizunoe, Yuhei, et al.
Publicado: (2017)

Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes—Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue
por: Kobayashi, Masaki, et al.
Publicado: (2020)

Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes
por: Kobayashi, Masaki, et al.
Publicado: (2020)

Mitochondrial intermediate peptidase is a novel regulator of sirtuin‐3 activation by caloric restriction
por: Kobayashi, Masaki, et al.
Publicado: (2017)

Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia
por: Sudo, Yuka, et al.
Publicado: (2018)

Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice
por: Mizunoe, Yuhei, et al.
Publicado: (2017)

Noninvasive and Safe Cell Viability Assay for Breast Cancer MCF-7 Cells Using Natural Food Pigment
por: Yamashita, Kyohei, et al.
Publicado: (2020)

Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan
por: Kobayashi, Masaki, et al.
Publicado: (2021)

Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals
por: Hoshino, Shunsuke, et al.
Publicado: (2018)

Sterol regulatory element‐binding protein‐1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction
por: Fujii, Namiki, et al.
Publicado: (2017)

The Poly(Adenosine Diphosphate-Ribose) Polymerase Inhibitor PJ34 Reduces Pulmonary Ischemia-Reperfusion Injury in Rats
por: Hatachi, Go, et al.
Publicado: (2014)

Modified Western blotting for insulin and other diabetes-associated peptide hormones
por: Okita, Naoyuki, et al.
Publicado: (2017)

WWP2 and its association with PTEN in endometrial cancer
por: Clements, Aine E., et al.
Publicado: (2015)

WWP2 is required for normal cell cycle progression
por: Choi, Byeong Hyeok, et al.
Publicado: (2015)

The emerging role of WWP1 in cancer development and progression
por: Hu, Xiaoli, et al.
Publicado: (2021)

CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions
por: Nakagawa, Yoshimi, et al.
Publicado: (2021)

WWP2-WWP1 Ubiquitin Ligase Complex Coordinated by PPM1G Maintains the Balance between Cellular p73 and ΔNp73 Levels
por: Chaudhary, Neelam, et al.
Publicado: (2014)

WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in mice
por: Fukumoto, Chonji, et al.
Publicado: (2014)

WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway: WWP2 interacted with PDCD4 ameliorates AS
por: Wang, Xingye, et al.
Publicado: (2022)

Wwp2 maintains cartilage homeostasis through regulation of Adamts5
por: Mokuda, Sho, et al.
Publicado: (2019)

WWP1 germline variants are associated with normocephalic autism spectrum disorder
por: Novelli, Giuseppe, et al.
Publicado: (2020)

WWP1 Deficiency Alleviates Cardiac Remodeling Induced by Simulated Microgravity
por: Zhong, Guohui, et al.
Publicado: (2021)

Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled
por: Mund, Thomas, et al.
Publicado: (2015)

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
por: Chen, Huimei, et al.
Publicado: (2019)

Contribution of PGC-1α to Obesity- and Caloric Restriction-Related Physiological Changes in White Adipose Tissue
por: Kobayashi, Masaki, et al.
Publicado: (2021)

Overexpression of WWP1 Promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma
por: Zhang, Xiao-Fei, et al.
Publicado: (2015)

The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemia
por: Sanarico, A G, et al.
Publicado: (2018)

WWP1 targeting MUC1 for ubiquitin-mediated lysosomal degradation to suppress carcinogenesis
por: Liao, Chunhua, et al.
Publicado: (2021)

Dysregulation of the miR‐16‐WWP1 signalling pathway leads to colorectal tumorigenesis
por: Chen, Xiaorui, et al.
Publicado: (2022)

The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid
por: Zou, Weiguo, et al.
Publicado: (2010)

Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells
por: Yu, Zhenlong, et al.
Publicado: (2016)

DNA damage induces expression of WWP1 to target ΔNp63α to degradation
por: Chen, Ji, et al.
Publicado: (2017)

WWP2 regulates SIRT1‐STAT3 acetylation and phosphorylation involved in hypertensive angiopathy
por: Zhang, Ying, et al.
Publicado: (2020)

Author Correction: WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
por: Chen, Huimei, et al.
Publicado: (2019)

AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation
por: Hwang, Daehee, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q7kvko37rl0mrhbq4ffben6b68