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Pharmacovigilance in perspective: drug withdrawals, data mining and policy implications
Considering that marketed drugs are not free from side effects, many countries have initiated pharmacovigilance programs. These initiatives have provided countries with methods of detection and prevention of adverse drug reactions at an earlier stage, thus preventing harm occurring in the larger pop...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050268/ https://www.ncbi.nlm.nih.gov/pubmed/32161643 http://dx.doi.org/10.12688/f1000research.21402.1 |
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author | Alomar, Muaed Palaian, Subish Al-tabakha, Moawia M. |
author_facet | Alomar, Muaed Palaian, Subish Al-tabakha, Moawia M. |
author_sort | Alomar, Muaed |
collection | PubMed |
description | Considering that marketed drugs are not free from side effects, many countries have initiated pharmacovigilance programs. These initiatives have provided countries with methods of detection and prevention of adverse drug reactions at an earlier stage, thus preventing harm occurring in the larger population. In this review, examples of drug withdrawals due to effective pharmacovigilance programs have been provided with details. In addition, information concerning data mining in pharmacovigilance, an effective method to assess pharmacoepidemiologic data and detecting signals for rare and uncommon side effects, is also examined, which is a method synchronized with information technology and advanced electronic tools. The importance of policy framework in relation to pharmacovigilance is discussed in detail, and country experiences upon implementation of pharmacovigilance policies is highlighted. |
format | Online Article Text |
id | pubmed-7050268 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-70502682020-03-10 Pharmacovigilance in perspective: drug withdrawals, data mining and policy implications Alomar, Muaed Palaian, Subish Al-tabakha, Moawia M. F1000Res Review Considering that marketed drugs are not free from side effects, many countries have initiated pharmacovigilance programs. These initiatives have provided countries with methods of detection and prevention of adverse drug reactions at an earlier stage, thus preventing harm occurring in the larger population. In this review, examples of drug withdrawals due to effective pharmacovigilance programs have been provided with details. In addition, information concerning data mining in pharmacovigilance, an effective method to assess pharmacoepidemiologic data and detecting signals for rare and uncommon side effects, is also examined, which is a method synchronized with information technology and advanced electronic tools. The importance of policy framework in relation to pharmacovigilance is discussed in detail, and country experiences upon implementation of pharmacovigilance policies is highlighted. F1000 Research Limited 2019-12-16 /pmc/articles/PMC7050268/ /pubmed/32161643 http://dx.doi.org/10.12688/f1000research.21402.1 Text en Copyright: © 2019 Alomar M et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Alomar, Muaed Palaian, Subish Al-tabakha, Moawia M. Pharmacovigilance in perspective: drug withdrawals, data mining and policy implications |
title | Pharmacovigilance in perspective: drug withdrawals, data mining and policy implications |
title_full | Pharmacovigilance in perspective: drug withdrawals, data mining and policy implications |
title_fullStr | Pharmacovigilance in perspective: drug withdrawals, data mining and policy implications |
title_full_unstemmed | Pharmacovigilance in perspective: drug withdrawals, data mining and policy implications |
title_short | Pharmacovigilance in perspective: drug withdrawals, data mining and policy implications |
title_sort | pharmacovigilance in perspective: drug withdrawals, data mining and policy implications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050268/ https://www.ncbi.nlm.nih.gov/pubmed/32161643 http://dx.doi.org/10.12688/f1000research.21402.1 |
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