Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders

Genome-wide association studies (GWAS) of complex traits, such as alcohol use disorders (AUD), usually identify variants in non-coding regions and cannot by themselves distinguish whether the associated variants are functional or in linkage disequilibrium with the functional variants. Transcriptome...

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Detalles Bibliográficos
Autores principales: Rao, Xi, Thapa, Kriti S., Chen, Andy B., Lin, Hai, Gao, Hongyu, Reiter, Jill L., Hargreaves, Katherine A., Ipe, Joseph, Lai, Dongbing, Xuei, Xiaoling, Wang, Yue, Gu, Hongmei, Kapoor, Manav, Farris, Sean P., Tischfield, Jay, Foroud, Tatiana, Goate, Alison M., Skaar, Todd C., Mayfield, R. Dayne, Edenberg, Howard J., Liu, Yunlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050407/
https://www.ncbi.nlm.nih.gov/pubmed/31477794
http://dx.doi.org/10.1038/s41380-019-0508-z

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