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Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

Cellular senescence is a potent tumor suppressor mechanism but also contributes to aging and aging-related diseases. Senescence is characterized by a stable cell cycle arrest and a complex proinflammatory secretome, termed the senescence-associated secretory phenotype (SASP). We recently discovered...

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Detalles Bibliográficos
Autores principales:	Vizioli, Maria Grazia, Liu, Tianhui, Miller, Karl N., Robertson, Neil A., Gilroy, Kathryn, Lagnado, Anthony B., Perez-Garcia, Arantxa, Kiourtis, Christos, Dasgupta, Nirmalya, Lei, Xue, Kruger, Patrick J., Nixon, Colin, Clark, William, Jurk, Diana, Bird, Thomas G., Passos, João F., Berger, Shelley L., Dou, Zhixun, Adams, Peter D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050483/ https://www.ncbi.nlm.nih.gov/pubmed/32001510 http://dx.doi.org/10.1101/gad.331272.119

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