HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots

Chromatin barriers prevent spurious interactions between regulatory elements and DNA-binding proteins. One such barrier, whose mechanism for overcoming is poorly understood, is access to recombination hot spots during meiosis. Here we show that the chromatin remodeler HELLS and DNA-binding protein P...

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Detalles Bibliográficos
Autores principales: Spruce, Catrina, Dlamini, Sibongakonke, Ananda, Guruprasad, Bronkema, Naomi, Tian, Hui, Paigen, Kenneth, Carter, Gregory W., Baker, Christopher L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050486/
https://www.ncbi.nlm.nih.gov/pubmed/32001511
http://dx.doi.org/10.1101/gad.333542.119

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