PARPs and ADP-ribosylation: 60 years on

Work on PARPs—a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins—has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts o...

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Detalles Bibliográficos
Autor principal: Kraus, W. Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050492/
https://www.ncbi.nlm.nih.gov/pubmed/32040441
http://dx.doi.org/10.1101/gad.336420.120
Descripción
Sumario:Work on PARPs—a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins—has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. This special focus section of Genes & Development includes seven reviews that highlight these discoveries and point the way forward for future advances in the field.

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