PARPs and ADP-ribosylation: 60 years on

Work on PARPs—a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins—has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts o...

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Detalles Bibliográficos
Autor principal: Kraus, W. Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050492/
https://www.ncbi.nlm.nih.gov/pubmed/32040441
http://dx.doi.org/10.1101/gad.336420.120
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author Kraus, W. Lee
author_facet Kraus, W. Lee
author_sort Kraus, W. Lee
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description Work on PARPs—a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins—has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. This special focus section of Genes & Development includes seven reviews that highlight these discoveries and point the way forward for future advances in the field.
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spelling pubmed-70504922020-09-01 PARPs and ADP-ribosylation: 60 years on Kraus, W. Lee Genes Dev Editorial Work on PARPs—a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins—has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. This special focus section of Genes & Development includes seven reviews that highlight these discoveries and point the way forward for future advances in the field. Cold Spring Harbor Laboratory Press 2020-03-01 /pmc/articles/PMC7050492/ /pubmed/32040441 http://dx.doi.org/10.1101/gad.336420.120 Text en © 2020 Kraus; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Editorial
Kraus, W. Lee
PARPs and ADP-ribosylation: 60 years on
title PARPs and ADP-ribosylation: 60 years on
title_full PARPs and ADP-ribosylation: 60 years on
title_fullStr PARPs and ADP-ribosylation: 60 years on
title_full_unstemmed PARPs and ADP-ribosylation: 60 years on
title_short PARPs and ADP-ribosylation: 60 years on
title_sort parps and adp-ribosylation: 60 years on
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050492/
https://www.ncbi.nlm.nih.gov/pubmed/32040441
http://dx.doi.org/10.1101/gad.336420.120
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