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Mannose‐capped lipoarabinomannan‐induced B10 cells decrease severity of dextran sodium sulphate‐induced inflammatory bowel disease in mice

Inflammatory bowel disease (IBD) is a chronic, non‐specific, inflammatory gastrointestinal disease that mainly consists of Crohn's disease and ulcerative colitis. However, the aetiology and pathogenesis of IBD are still unclear. B10 (IL‐10 producing regulatory B) cells, a subset of regulatory B...

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Autores principales: Yuan, Chun-Hui, Li, Xin, Luo, Liang, Wang, Ya-Ping, Zhang, Dong-Li, Zhou, Kai‐Liang, Zhang, Xiao‐Lian, Pan, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050505/
https://www.ncbi.nlm.nih.gov/pubmed/31657484
http://dx.doi.org/10.1111/sji.12843
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author Yuan, Chun-Hui
Li, Xin
Luo, Liang
Wang, Ya-Ping
Zhang, Dong-Li
Zhou, Kai‐Liang
Zhang, Xiao‐Lian
Pan, Qin
author_facet Yuan, Chun-Hui
Li, Xin
Luo, Liang
Wang, Ya-Ping
Zhang, Dong-Li
Zhou, Kai‐Liang
Zhang, Xiao‐Lian
Pan, Qin
author_sort Yuan, Chun-Hui
collection PubMed
description Inflammatory bowel disease (IBD) is a chronic, non‐specific, inflammatory gastrointestinal disease that mainly consists of Crohn's disease and ulcerative colitis. However, the aetiology and pathogenesis of IBD are still unclear. B10 (IL‐10 producing regulatory B) cells, a subset of regulatory B cells, are known to contribute to intestinal homeostasis and the aberrant frequency of B10 cells is associated with IBD. We have recently reported that B10 cells can be induced by ManLAM (mannose‐capped lipoarabinomannan), a major cell‐wall lipoglycan of M tb (Mycobacterium tuberculosis). In the current study, the ManLAM‐induced B10 cells were adoptively transferred into IL(interleukin)‐10(−/−) mice and the roles of ManLAM‐induced B10 cells were investigated in DSS (dextran sodium sulphate)‐induced IBD model. ManLAM‐induced B10 cells decrease colitis severity in the mice. The B10 cells downregulate Th1 polarization in spleen and MLNs (mesenteric lymph nodes) of DSS‐treated mice. These results suggest that IL‐10 production by ManLAM‐treated B cells contributes to keeping the balance between CD4(+) T cell subsets and protect mice from DSS‐induced IBD.
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spelling pubmed-70505052020-03-09 Mannose‐capped lipoarabinomannan‐induced B10 cells decrease severity of dextran sodium sulphate‐induced inflammatory bowel disease in mice Yuan, Chun-Hui Li, Xin Luo, Liang Wang, Ya-Ping Zhang, Dong-Li Zhou, Kai‐Liang Zhang, Xiao‐Lian Pan, Qin Scand J Immunol Experimental Immunology Inflammatory bowel disease (IBD) is a chronic, non‐specific, inflammatory gastrointestinal disease that mainly consists of Crohn's disease and ulcerative colitis. However, the aetiology and pathogenesis of IBD are still unclear. B10 (IL‐10 producing regulatory B) cells, a subset of regulatory B cells, are known to contribute to intestinal homeostasis and the aberrant frequency of B10 cells is associated with IBD. We have recently reported that B10 cells can be induced by ManLAM (mannose‐capped lipoarabinomannan), a major cell‐wall lipoglycan of M tb (Mycobacterium tuberculosis). In the current study, the ManLAM‐induced B10 cells were adoptively transferred into IL(interleukin)‐10(−/−) mice and the roles of ManLAM‐induced B10 cells were investigated in DSS (dextran sodium sulphate)‐induced IBD model. ManLAM‐induced B10 cells decrease colitis severity in the mice. The B10 cells downregulate Th1 polarization in spleen and MLNs (mesenteric lymph nodes) of DSS‐treated mice. These results suggest that IL‐10 production by ManLAM‐treated B cells contributes to keeping the balance between CD4(+) T cell subsets and protect mice from DSS‐induced IBD. John Wiley and Sons Inc. 2019-11-24 2020-02 /pmc/articles/PMC7050505/ /pubmed/31657484 http://dx.doi.org/10.1111/sji.12843 Text en © 2019 The Authors. Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of The Scandinavian Foundation for Immunology This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Experimental Immunology
Yuan, Chun-Hui
Li, Xin
Luo, Liang
Wang, Ya-Ping
Zhang, Dong-Li
Zhou, Kai‐Liang
Zhang, Xiao‐Lian
Pan, Qin
Mannose‐capped lipoarabinomannan‐induced B10 cells decrease severity of dextran sodium sulphate‐induced inflammatory bowel disease in mice
title Mannose‐capped lipoarabinomannan‐induced B10 cells decrease severity of dextran sodium sulphate‐induced inflammatory bowel disease in mice
title_full Mannose‐capped lipoarabinomannan‐induced B10 cells decrease severity of dextran sodium sulphate‐induced inflammatory bowel disease in mice
title_fullStr Mannose‐capped lipoarabinomannan‐induced B10 cells decrease severity of dextran sodium sulphate‐induced inflammatory bowel disease in mice
title_full_unstemmed Mannose‐capped lipoarabinomannan‐induced B10 cells decrease severity of dextran sodium sulphate‐induced inflammatory bowel disease in mice
title_short Mannose‐capped lipoarabinomannan‐induced B10 cells decrease severity of dextran sodium sulphate‐induced inflammatory bowel disease in mice
title_sort mannose‐capped lipoarabinomannan‐induced b10 cells decrease severity of dextran sodium sulphate‐induced inflammatory bowel disease in mice
topic Experimental Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050505/
https://www.ncbi.nlm.nih.gov/pubmed/31657484
http://dx.doi.org/10.1111/sji.12843
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