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netNMF-sc: leveraging gene–gene interactions for imputation and dimensionality reduction in single-cell expression analysis
Single-cell RNA-sequencing (scRNA-seq) enables high-throughput measurement of RNA expression in single cells. However, because of technical limitations, scRNA-seq data often contain zero counts for many transcripts in individual cells. These zero counts, or dropout events, complicate the analysis of...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050525/ https://www.ncbi.nlm.nih.gov/pubmed/31992614 http://dx.doi.org/10.1101/gr.251603.119 |