A HOTAIR regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes

Temozolomide (TMZ) is a frequently used chemotherapy for glioma; however, chemoresistance is a major problem limiting its effectiveness. Thus, knowledge of mechanisms underlying this outcome could improve patient prognosis. Here, we report that deletion of a regulatory element in the HOTAIR locus in...

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Detalles Bibliográficos
Autores principales: Zhang, Lei, He, Anshun, Chen, Bohan, Bi, Jinfang, Chen, Jun, Guo, Dianhao, Qian, Yuyang, Wang, Wenbin, Shi, Tengfei, Zhao, Zhongfang, Shi, Jiandang, An, Woojin, Attenello, Frank, Lu, Wange
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050528/
https://www.ncbi.nlm.nih.gov/pubmed/31953347
http://dx.doi.org/10.1101/gr.251058.119

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