Improving the aqueous solubility of HCV‐E2 glycoprotein epitope mimics by cyclization using POLAR hinges

In this research we describe the improvement of the water‐solubility of cyclic epitope mimics based on the HCV E2 glycoprotein by incorporation of suitable polar hinges. The poor solubility of epitope mimics based on peptide sequences in the envelope (E2) protein hampered their synthesis and purific...

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Detalles Bibliográficos
Autores principales: Meuleman, Theodorus J., Cowton, Vanessa M., Patel, Arvind H., Liskamp, Rob M.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050536/
https://www.ncbi.nlm.nih.gov/pubmed/31984607
http://dx.doi.org/10.1002/psc.3222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050536/
https://www.ncbi.nlm.nih.gov/pubmed/31984607
http://dx.doi.org/10.1002/psc.3222

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