Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models

AIM: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. MATERIALS & METHODS: We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative muri...

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Detalles Bibliográficos
Autores principales: Giolito, María V, Camacho, Cristian M, Martinez-Amezaga, Maitena, Traficante, Carla I, Giordano, Rocío A, Cornier, Patricia G, Mata, Ernesto G, Delpiccolo, Carina ML, Boggián, Dora B, Giúdice, Antonela Del, Mainetti, Leandro E, Scharovsky, Olga G, Rozados, Viviana R, Rico, María J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050605/
https://www.ncbi.nlm.nih.gov/pubmed/32140251
http://dx.doi.org/10.2144/fsoa-2019-0057
Descripción
Sumario:AIM: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. MATERIALS & METHODS: We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative murine mammary adenocarcinoma tumors. RESULTS & CONCLUSION: Three compounds were selected because of their high antitumor activity and their low toxicity to normal cells. Their effect on tumor cells apoptosis, clonogenicity and migratory capacity, were determined. We found that the selected compounds showed inhibition of viability and clonogenic capacity, and promotion of apoptosis. They also decreased the migratory capacity of tumor cells. The results obtained suggest the likelihood of their future use as antitumor and/or antimetastatic agents.

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