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Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
AIM: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. MATERIALS & METHODS: We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative muri...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Science Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050605/ https://www.ncbi.nlm.nih.gov/pubmed/32140251 http://dx.doi.org/10.2144/fsoa-2019-0057 |
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author | Giolito, María V Camacho, Cristian M Martinez-Amezaga, Maitena Traficante, Carla I Giordano, Rocío A Cornier, Patricia G Mata, Ernesto G Delpiccolo, Carina ML Boggián, Dora B Giúdice, Antonela Del Mainetti, Leandro E Scharovsky, Olga G Rozados, Viviana R Rico, María J |
author_facet | Giolito, María V Camacho, Cristian M Martinez-Amezaga, Maitena Traficante, Carla I Giordano, Rocío A Cornier, Patricia G Mata, Ernesto G Delpiccolo, Carina ML Boggián, Dora B Giúdice, Antonela Del Mainetti, Leandro E Scharovsky, Olga G Rozados, Viviana R Rico, María J |
author_sort | Giolito, María V |
collection | PubMed |
description | AIM: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. MATERIALS & METHODS: We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative murine mammary adenocarcinoma tumors. RESULTS & CONCLUSION: Three compounds were selected because of their high antitumor activity and their low toxicity to normal cells. Their effect on tumor cells apoptosis, clonogenicity and migratory capacity, were determined. We found that the selected compounds showed inhibition of viability and clonogenic capacity, and promotion of apoptosis. They also decreased the migratory capacity of tumor cells. The results obtained suggest the likelihood of their future use as antitumor and/or antimetastatic agents. |
format | Online Article Text |
id | pubmed-7050605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Future Science Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-70506052020-03-05 Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models Giolito, María V Camacho, Cristian M Martinez-Amezaga, Maitena Traficante, Carla I Giordano, Rocío A Cornier, Patricia G Mata, Ernesto G Delpiccolo, Carina ML Boggián, Dora B Giúdice, Antonela Del Mainetti, Leandro E Scharovsky, Olga G Rozados, Viviana R Rico, María J Future Sci OA Research Article AIM: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. MATERIALS & METHODS: We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative murine mammary adenocarcinoma tumors. RESULTS & CONCLUSION: Three compounds were selected because of their high antitumor activity and their low toxicity to normal cells. Their effect on tumor cells apoptosis, clonogenicity and migratory capacity, were determined. We found that the selected compounds showed inhibition of viability and clonogenic capacity, and promotion of apoptosis. They also decreased the migratory capacity of tumor cells. The results obtained suggest the likelihood of their future use as antitumor and/or antimetastatic agents. Future Science Ltd 2020-01-23 /pmc/articles/PMC7050605/ /pubmed/32140251 http://dx.doi.org/10.2144/fsoa-2019-0057 Text en © 2020 Maria Jose Rico This work is licensed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Research Article Giolito, María V Camacho, Cristian M Martinez-Amezaga, Maitena Traficante, Carla I Giordano, Rocío A Cornier, Patricia G Mata, Ernesto G Delpiccolo, Carina ML Boggián, Dora B Giúdice, Antonela Del Mainetti, Leandro E Scharovsky, Olga G Rozados, Viviana R Rico, María J Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models |
title | Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models |
title_full | Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models |
title_fullStr | Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models |
title_full_unstemmed | Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models |
title_short | Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models |
title_sort | antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050605/ https://www.ncbi.nlm.nih.gov/pubmed/32140251 http://dx.doi.org/10.2144/fsoa-2019-0057 |
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