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Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models

AIM: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. MATERIALS & METHODS: We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative muri...

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Autores principales: Giolito, María V, Camacho, Cristian M, Martinez-Amezaga, Maitena, Traficante, Carla I, Giordano, Rocío A, Cornier, Patricia G, Mata, Ernesto G, Delpiccolo, Carina ML, Boggián, Dora B, Giúdice, Antonela Del, Mainetti, Leandro E, Scharovsky, Olga G, Rozados, Viviana R, Rico, María J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050605/
https://www.ncbi.nlm.nih.gov/pubmed/32140251
http://dx.doi.org/10.2144/fsoa-2019-0057
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author Giolito, María V
Camacho, Cristian M
Martinez-Amezaga, Maitena
Traficante, Carla I
Giordano, Rocío A
Cornier, Patricia G
Mata, Ernesto G
Delpiccolo, Carina ML
Boggián, Dora B
Giúdice, Antonela Del
Mainetti, Leandro E
Scharovsky, Olga G
Rozados, Viviana R
Rico, María J
author_facet Giolito, María V
Camacho, Cristian M
Martinez-Amezaga, Maitena
Traficante, Carla I
Giordano, Rocío A
Cornier, Patricia G
Mata, Ernesto G
Delpiccolo, Carina ML
Boggián, Dora B
Giúdice, Antonela Del
Mainetti, Leandro E
Scharovsky, Olga G
Rozados, Viviana R
Rico, María J
author_sort Giolito, María V
collection PubMed
description AIM: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. MATERIALS & METHODS: We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative murine mammary adenocarcinoma tumors. RESULTS & CONCLUSION: Three compounds were selected because of their high antitumor activity and their low toxicity to normal cells. Their effect on tumor cells apoptosis, clonogenicity and migratory capacity, were determined. We found that the selected compounds showed inhibition of viability and clonogenic capacity, and promotion of apoptosis. They also decreased the migratory capacity of tumor cells. The results obtained suggest the likelihood of their future use as antitumor and/or antimetastatic agents.
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spelling pubmed-70506052020-03-05 Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models Giolito, María V Camacho, Cristian M Martinez-Amezaga, Maitena Traficante, Carla I Giordano, Rocío A Cornier, Patricia G Mata, Ernesto G Delpiccolo, Carina ML Boggián, Dora B Giúdice, Antonela Del Mainetti, Leandro E Scharovsky, Olga G Rozados, Viviana R Rico, María J Future Sci OA Research Article AIM: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. MATERIALS & METHODS: We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative murine mammary adenocarcinoma tumors. RESULTS & CONCLUSION: Three compounds were selected because of their high antitumor activity and their low toxicity to normal cells. Their effect on tumor cells apoptosis, clonogenicity and migratory capacity, were determined. We found that the selected compounds showed inhibition of viability and clonogenic capacity, and promotion of apoptosis. They also decreased the migratory capacity of tumor cells. The results obtained suggest the likelihood of their future use as antitumor and/or antimetastatic agents. Future Science Ltd 2020-01-23 /pmc/articles/PMC7050605/ /pubmed/32140251 http://dx.doi.org/10.2144/fsoa-2019-0057 Text en © 2020 Maria Jose Rico This work is licensed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Giolito, María V
Camacho, Cristian M
Martinez-Amezaga, Maitena
Traficante, Carla I
Giordano, Rocío A
Cornier, Patricia G
Mata, Ernesto G
Delpiccolo, Carina ML
Boggián, Dora B
Giúdice, Antonela Del
Mainetti, Leandro E
Scharovsky, Olga G
Rozados, Viviana R
Rico, María J
Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
title Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
title_full Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
title_fullStr Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
title_full_unstemmed Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
title_short Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
title_sort antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050605/
https://www.ncbi.nlm.nih.gov/pubmed/32140251
http://dx.doi.org/10.2144/fsoa-2019-0057
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