Aromatic Fluorination of Multiblock Amphiphile Enhances Its Incorporation into Lipid Bilayer Membranes

We designed multiblock amphiphiles AmF and AmH, which consist of perfluorinated and non‐fluorinated hydrophobic units, respectively. Absorption spectroscopy revealed that both amphiphiles are molecularly dispersed in organic solvent, while they form aggregates under aqueous conditions. Furthermore,...

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Detalles Bibliográficos
Autores principales: Sasaki, Ryo, Sato, Kohei, Kinbara, Kazushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050654/
https://www.ncbi.nlm.nih.gov/pubmed/32154050
http://dx.doi.org/10.1002/open.201900374
Descripción
Sumario:We designed multiblock amphiphiles AmF and AmH, which consist of perfluorinated and non‐fluorinated hydrophobic units, respectively. Absorption spectroscopy revealed that both amphiphiles are molecularly dispersed in organic solvent, while they form aggregates under aqueous conditions. Furthermore, we investigated whether AmF and AmH can be incorporated into DOPC lipid bilayer membranes, and found that the maximum concentration of AmF that can be incorporated into DOPC lipid bilayer membranes is 43 times higher than that of AmH.

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