Nicotinamide Limits Replication of Mycobacterium tuberculosis and Bacille Calmette-Guérin Within Macrophages

Novel antimicrobials for treatment of Mycobacterium tuberculosis are needed. We hypothesized that nicotinamide (NAM) and nicotinic acid (NA) modulate macrophage function to restrict M. tuberculosis replication in addition to their direct antimicrobial properties. Both compounds had modest activity i...

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Detalles Bibliográficos
Autores principales: Simmons, Jason D, Peterson, Glenna J, Campo, Monica, Lohmiller, Jenny, Skerrett, Shawn J, Tunaru, Sorin, Offermanns, Stefan, Sherman, David R, Hawn, Thomas R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050990/
https://www.ncbi.nlm.nih.gov/pubmed/31665359
http://dx.doi.org/10.1093/infdis/jiz541

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