Cargando…

MCLENA-1: A Phase II Clinical Trial for the Assessment of Safety, Tolerability, and Efficacy of Lenalidomide in Patients with Mild Cognitive Impairment Due to Alzheimer’s Disease

With the general population reaching higher ages, a surge in Alzheimer’s disease (AD) incidence will happen in the coming decades, putting a heavy burden on families and healthcare systems Worldwide. This emphasizes the pressing need for AD therapeutic interventions. Accumulating evidence indicates...

Descripción completa

Detalles Bibliográficos
Autores principales:	Decourt, Boris, Wilson, Jeffrey, Ritter, Aaron, Dardis, Christopher, DiFilippo, Frank P, Zhuang, Xiaowei, Cordes, Dietmar, Lee, Garam, Fulkerson, Nadia D, St Rose, Tessa, Hartley, Katurah, Sabbagh, Marwan N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051033/ https://www.ncbi.nlm.nih.gov/pubmed/32123490 http://dx.doi.org/10.2147/oajct.s221914

Ejemplares similares

Does Informant-Based Reporting of Cognitive Decline Correlate with Age-Adjusted Hippocampal Volume in Mild Cognitive Impairment and Alzheimer’s Disease?
por: Sabbagh, Marwan, et al.
Publicado: (2021)

The Cause of Alzheimer’s Disease: The Theory of Multipathology Convergence to Chronic Neuronal Stress
por: Decourt, Boris, et al.
Publicado: (2022)

Relationship of sex differences in cortical thickness and memory among cognitively healthy subjects and individuals with mild cognitive impairment and Alzheimer disease
por: Cieri, Filippo, et al.
Publicado: (2022)

Review of Advanced Drug Trials Focusing on the Reduction of Brain Beta-Amyloid to Prevent and Treat Dementia
por: Decourt, Boris, et al.
Publicado: (2022)

Alzheimer's disease drug development pipeline: 2019
por: Cummings, Jeffrey, et al.
Publicado: (2019)

Alzheimer's disease drug development pipeline: 2020
por: Cummings, Jeffrey, et al.
Publicado: (2020)

Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer’s Related Pathological Changes in Down Syndrome
por: DeCourt, Boris, et al.
Publicado: (2013)

Critical Appraisal of Amyloid Lowering Agents in AD
por: Decourt, Boris, et al.
Publicado: (2021)

Is diabetes associated with increased pathological burden in Alzheimer's disease?
por: Sadrolashrafi, Kaviyon, et al.
Publicado: (2021)

Longitudinal Changes in Cognitive Functioning and Brain Structure in Professional Boxers and Mixed Martial Artists After They Stop Fighting
por: Zhuang, Xiaowei, et al.
Publicado: (2022)

Brain Entropy During Aging Through a Free Energy Principle Approach
por: Cieri, Filippo, et al.
Publicado: (2021)

A technical review of canonical correlation analysis for neuroscience applications
por: Zhuang, Xiaowei, et al.
Publicado: (2020)

Platelet BACE1 levels as a possible biomarker for Alzheimer’s disease
por: Decourt, Boris, et al.
Publicado: (2013)

Sex Modulates the Pathological Aging Effect on Caudate Functional Connectivity in Mild Cognitive Impairment
por: Yang, Zhengshi, et al.
Publicado: (2022)

Broader Considerations of Higher Doses of Donepezil in the Treatment of Mild, Moderate, and Severe Alzheimer's Disease
por: Berk, Camryn, et al.
Publicado: (2012)

The effect of statins on rate of cognitive decline in mild cognitive impairment
por: Smith, Kyle B., et al.
Publicado: (2017)

Olfaction and Anxiety Are Differently Associated in Men and Women in Cognitive Physiological and Pathological Aging
por: Cieri, Filippo, et al.
Publicado: (2023)

Robust Motion Regression of Resting-State Data Using a Convolutional Neural Network Model
por: Yang, Zhengshi, et al.
Publicado: (2019)

Disentangling time series between brain tissues improves fMRI data quality using a time-dependent deep neural network
por: Yang, Zhengshi, et al.
Publicado: (2020)

What Promises the CJD Diagnosis in a Case of Rapidly Progressive Dementia?
por: Aslam, Sana, et al.
Publicado: (2018)

Lenalidomide versus lenalidomide + dexamethasone prolonged treatment after second‐line lenalidomide + dexamethasone induction in multiple myeloma
por: Lund, Johan, et al.
Publicado: (2018)

Single-scale time-dependent window-sizes in sliding-window dynamic functional connectivity analysis: A validation study
por: Zhuang, Xiaowei, et al.
Publicado: (2020)

Lenalidomide-Associated ITP
por: Herold, Christina I., et al.
Publicado: (2011)

Informant-reported cognitive symptoms that predict amnestic mild cognitive impairment
por: Malek-Ahmadi, Michael, et al.
Publicado: (2012)

KIF6 719Arg Carrier Status Association with Homocysteine and C-Reactive Protein in Amnestic Mild Cognitive Impairment and Alzheimer's Disease Patients
por: Malek-Ahmadi, Michael, et al.
Publicado: (2013)

Potential Neuroregenerative and Neuroprotective Effects of Uridine/Choline-Enriched Multinutrient Dietary Intervention for Mild Cognitive Impairment: A Narrative Review
por: Baumel, Barry S., et al.
Publicado: (2020)

Downregulation of Chemokine CCL20 Involved in Myeloma Cells Resistant to Elotuzumab and Lenalidomide
por: Wang, Huihan, et al.
Publicado: (2021)

Effect of TTP488 in patients with mild to moderate Alzheimer’s disease
por: Burstein, Aaron H, et al.
Publicado: (2014)

Lenalidomide in Combination with Arsenic Trioxide: an Effective Therapy for Primary Effusion Lymphoma
por: Moodad, Sara, et al.
Publicado: (2020)

Carfilzomib–lenalidomide–dexamethasone vs lenalidomide–dexamethasone in relapsed multiple myeloma by previous treatment
por: Dimopoulos, M A, et al.
Publicado: (2017)

Lenalidomide-associated B-cell ALL: clinical and pathologic correlates and sensitivity to lenalidomide withdrawal
por: Geyer, Mark B., et al.
Publicado: (2023)

Performing Sparse Regularization and Dimension Reduction Simultaneously in Multimodal Data Fusion
por: Yang, Zhengshi, et al.
Publicado: (2019)

Lenalidomide and Chronic Lymphocytic Leukemia
por: González-Rodríguez, Ana Pilar, et al.
Publicado: (2013)

Clinical Pharmacokinetics and Pharmacodynamics of Lenalidomide
por: Chen, Nianhang, et al.
Publicado: (2016)

Hyperbilirubinemia following lenalidomide administration
por: Azmy, Veronica, et al.
Publicado: (2018)

Lenalidomide‐induced eosinophilic pneumonia
por: Toma, Andrew, et al.
Publicado: (2017)

Therapy of Angiosarcoma with Thalidomide and Lenalidomide
por: Mattes, M. Jules, et al.
Publicado: (2021)

Severe Lenalidomide-Associated Hyperbilirubinemia
por: Gildea, Daniel T, et al.
Publicado: (2023)

Treatment of Lenalidomide Exposed or Refractory Multiple Myeloma: Network Meta-Analysis of Lenalidomide-Sparing Regimens
por: Botta, Cirino, et al.
Publicado: (2021)

Multifunction RF Systems for Naval Platforms
por: Moo, Peter W., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_njt24kk5pvs5dl16rmbtl8mjil