Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia

The drug efflux pump ABCB1 (ATP binding cassette subfamily B member 1) confers chemotherapy resistance in acute myeloid leukemia (AML). We recently identified an ABCB1 enhancer that is activated in response to a range of cellular stressors, including anthracycline chemotherapy. Stress drives increas...

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Detalles Bibliográficos
Autores principales: Williams, Mark S., Somervaille, Tim C. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051134/
https://www.ncbi.nlm.nih.gov/pubmed/32158919
http://dx.doi.org/10.1080/23723556.2019.1705730
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author Williams, Mark S.
Somervaille, Tim C. P.
author_facet Williams, Mark S.
Somervaille, Tim C. P.
author_sort Williams, Mark S.
collection PubMed
description The drug efflux pump ABCB1 (ATP binding cassette subfamily B member 1) confers chemotherapy resistance in acute myeloid leukemia (AML). We recently identified an ABCB1 enhancer that is activated in response to a range of cellular stressors, including anthracycline chemotherapy. Stress drives increased ABCB1 expression and allows leukemia cells to escape from targeted third-generation ABCB1 inhibition.
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spelling pubmed-70511342020-09-28 Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia Williams, Mark S. Somervaille, Tim C. P. Mol Cell Oncol Author's Views The drug efflux pump ABCB1 (ATP binding cassette subfamily B member 1) confers chemotherapy resistance in acute myeloid leukemia (AML). We recently identified an ABCB1 enhancer that is activated in response to a range of cellular stressors, including anthracycline chemotherapy. Stress drives increased ABCB1 expression and allows leukemia cells to escape from targeted third-generation ABCB1 inhibition. Taylor & Francis 2020-01-08 /pmc/articles/PMC7051134/ /pubmed/32158919 http://dx.doi.org/10.1080/23723556.2019.1705730 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Williams, Mark S.
Somervaille, Tim C. P.
Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia
title Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia
title_full Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia
title_fullStr Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia
title_full_unstemmed Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia
title_short Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia
title_sort dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051134/
https://www.ncbi.nlm.nih.gov/pubmed/32158919
http://dx.doi.org/10.1080/23723556.2019.1705730
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