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Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia
The drug efflux pump ABCB1 (ATP binding cassette subfamily B member 1) confers chemotherapy resistance in acute myeloid leukemia (AML). We recently identified an ABCB1 enhancer that is activated in response to a range of cellular stressors, including anthracycline chemotherapy. Stress drives increas...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051134/ https://www.ncbi.nlm.nih.gov/pubmed/32158919 http://dx.doi.org/10.1080/23723556.2019.1705730 |