New control of the senescence barrier in breast cancer

Normal cells exposed to cancer-causing events respond by triggering cellular senescence, a stress response which halts cell proliferation and constitutes a protective anti-cancer barrier. We have uncovered a previously unknown signaling pathway implicating p21-activated kinase 4 (PAK4) in the contro...

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Detalles Bibliográficos
Autores principales: Costa, Tânia D. F., Strömblad, Staffan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051141/
https://www.ncbi.nlm.nih.gov/pubmed/32158912
http://dx.doi.org/10.1080/23723556.2019.1684129
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author Costa, Tânia D. F.
Strömblad, Staffan
author_facet Costa, Tânia D. F.
Strömblad, Staffan
author_sort Costa, Tânia D. F.
collection PubMed
description Normal cells exposed to cancer-causing events respond by triggering cellular senescence, a stress response which halts cell proliferation and constitutes a protective anti-cancer barrier. We have uncovered a previously unknown signaling pathway implicating p21-activated kinase 4 (PAK4) in the control of senescence in breast cancer, via the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit RELB and the CCAAT-enhancer-binding protein beta (C/EBPβ).
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spelling pubmed-70511412020-09-28 New control of the senescence barrier in breast cancer Costa, Tânia D. F. Strömblad, Staffan Mol Cell Oncol Author's Views Normal cells exposed to cancer-causing events respond by triggering cellular senescence, a stress response which halts cell proliferation and constitutes a protective anti-cancer barrier. We have uncovered a previously unknown signaling pathway implicating p21-activated kinase 4 (PAK4) in the control of senescence in breast cancer, via the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit RELB and the CCAAT-enhancer-binding protein beta (C/EBPβ). Taylor & Francis 2020-01-20 /pmc/articles/PMC7051141/ /pubmed/32158912 http://dx.doi.org/10.1080/23723556.2019.1684129 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author's Views
Costa, Tânia D. F.
Strömblad, Staffan
New control of the senescence barrier in breast cancer
title New control of the senescence barrier in breast cancer
title_full New control of the senescence barrier in breast cancer
title_fullStr New control of the senescence barrier in breast cancer
title_full_unstemmed New control of the senescence barrier in breast cancer
title_short New control of the senescence barrier in breast cancer
title_sort new control of the senescence barrier in breast cancer
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051141/
https://www.ncbi.nlm.nih.gov/pubmed/32158912
http://dx.doi.org/10.1080/23723556.2019.1684129
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