Transcription-dependent DNA double-strand breaks and human disease

Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoi...

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Autores principales: Cristini, Agnese, Gromak, Natalia, Sordet, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051148/
https://www.ncbi.nlm.nih.gov/pubmed/32158914
http://dx.doi.org/10.1080/23723556.2019.1691905
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author Cristini, Agnese
Gromak, Natalia
Sordet, Olivier
author_facet Cristini, Agnese
Gromak, Natalia
Sordet, Olivier
author_sort Cristini, Agnese
collection PubMed
description Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoisomerase I and may underlie neurological disorders and cancers.
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spelling pubmed-70511482020-09-28 Transcription-dependent DNA double-strand breaks and human disease Cristini, Agnese Gromak, Natalia Sordet, Olivier Mol Cell Oncol Author's Views Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoisomerase I and may underlie neurological disorders and cancers. Taylor & Francis 2020-01-10 /pmc/articles/PMC7051148/ /pubmed/32158914 http://dx.doi.org/10.1080/23723556.2019.1691905 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Cristini, Agnese
Gromak, Natalia
Sordet, Olivier
Transcription-dependent DNA double-strand breaks and human disease
title Transcription-dependent DNA double-strand breaks and human disease
title_full Transcription-dependent DNA double-strand breaks and human disease
title_fullStr Transcription-dependent DNA double-strand breaks and human disease
title_full_unstemmed Transcription-dependent DNA double-strand breaks and human disease
title_short Transcription-dependent DNA double-strand breaks and human disease
title_sort transcription-dependent dna double-strand breaks and human disease
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051148/
https://www.ncbi.nlm.nih.gov/pubmed/32158914
http://dx.doi.org/10.1080/23723556.2019.1691905
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