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Transcription-dependent DNA double-strand breaks and human disease

Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoi...

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Detalles Bibliográficos
Autores principales:	Cristini, Agnese, Gromak, Natalia, Sordet, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Author's Views
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051148/ https://www.ncbi.nlm.nih.gov/pubmed/32158914 http://dx.doi.org/10.1080/23723556.2019.1691905

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