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Why does a mitochondrion need its individual cristae to be functionally autonomous?
We demonstrated that individual cristae in one mitochondrion function as autonomous electrochemical units, with this autonomy being maintained by cristae junction modulators. Here, I will summarize our novel findings, discuss the advantages of cristae insulation and reconcile this newly characterize...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051166/ https://www.ncbi.nlm.nih.gov/pubmed/32158918 http://dx.doi.org/10.1080/23723556.2019.1705119 |
| Sumario: | We demonstrated that individual cristae in one mitochondrion function as autonomous electrochemical units, with this autonomy being maintained by cristae junction modulators. Here, I will summarize our novel findings, discuss the advantages of cristae insulation and reconcile this newly characterized cristae autonomy with previous studies showing coordinated cristae function. |
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