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Zika virus infection in the genital tract of non-pregnant females: a systematic review

This review provides a general overview on the positivity and persistence of Zika virus (ZIKV) in female genital tract (FGT) of non-pregnant women and animals, as well as in cell cultures, and its influence on FGT health. We performed a systematic review based on the PRISMA statement to identify stu...

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Autores principales: Morelli, Fabrício, Souza, Raquel Pantarotto, da Cruz, Taís Elisângela, Damke, Gabrielle Marconi Zago Ferreira, Damke, Edilson, Suehiro, Tamy Tuani, da Silva, Vânia Ramos Sela, Consolaro, Marcia Edilaine Lopes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051180/
https://www.ncbi.nlm.nih.gov/pubmed/32130356
http://dx.doi.org/10.1590/S1678-9946202062016
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author Morelli, Fabrício
Souza, Raquel Pantarotto
da Cruz, Taís Elisângela
Damke, Gabrielle Marconi Zago Ferreira
Damke, Edilson
Suehiro, Tamy Tuani
da Silva, Vânia Ramos Sela
Consolaro, Marcia Edilaine Lopes
author_facet Morelli, Fabrício
Souza, Raquel Pantarotto
da Cruz, Taís Elisângela
Damke, Gabrielle Marconi Zago Ferreira
Damke, Edilson
Suehiro, Tamy Tuani
da Silva, Vânia Ramos Sela
Consolaro, Marcia Edilaine Lopes
author_sort Morelli, Fabrício
collection PubMed
description This review provides a general overview on the positivity and persistence of Zika virus (ZIKV) in female genital tract (FGT) of non-pregnant women and animals, as well as in cell cultures, and its influence on FGT health. We performed a systematic review based on the PRISMA statement to identify studies focused on “Zika virus” and “non-pregnant female” in PubMed, Embase, Scopus Scholar and Web of Knowledge databases of full-text papers and abstracts published in English, with no restrictions regarding the initial date of publication, up to August 2019. Our search terms yielded 625 records, that were 108 after removal of duplicates, leaving 517 items for title and abstract reviews. Of these, 475 did not meet the inclusion criteria, leaving 42 records for full-text review and resulting in the exclusion of 6 additional records. The remaining 36 met our inclusion criteria. Variations were observed regarding the presence and persistence of ZIKV in lower and upper genital samples. However, the FGT was the place in which ZIKV RNA has been detected, sometimes for relatively long periods, even after the clearance from blood and urine. In addition to the vagina and cervix, the endometrium, uterus and ovary (oocytes and follicles) could also be involved in persistent ZIKV infections. Further prospective studies are needed to assess the effect of ZIKV on FGT health.
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spelling pubmed-70511802020-03-10 Zika virus infection in the genital tract of non-pregnant females: a systematic review Morelli, Fabrício Souza, Raquel Pantarotto da Cruz, Taís Elisângela Damke, Gabrielle Marconi Zago Ferreira Damke, Edilson Suehiro, Tamy Tuani da Silva, Vânia Ramos Sela Consolaro, Marcia Edilaine Lopes Rev Inst Med Trop Sao Paulo Review This review provides a general overview on the positivity and persistence of Zika virus (ZIKV) in female genital tract (FGT) of non-pregnant women and animals, as well as in cell cultures, and its influence on FGT health. We performed a systematic review based on the PRISMA statement to identify studies focused on “Zika virus” and “non-pregnant female” in PubMed, Embase, Scopus Scholar and Web of Knowledge databases of full-text papers and abstracts published in English, with no restrictions regarding the initial date of publication, up to August 2019. Our search terms yielded 625 records, that were 108 after removal of duplicates, leaving 517 items for title and abstract reviews. Of these, 475 did not meet the inclusion criteria, leaving 42 records for full-text review and resulting in the exclusion of 6 additional records. The remaining 36 met our inclusion criteria. Variations were observed regarding the presence and persistence of ZIKV in lower and upper genital samples. However, the FGT was the place in which ZIKV RNA has been detected, sometimes for relatively long periods, even after the clearance from blood and urine. In addition to the vagina and cervix, the endometrium, uterus and ovary (oocytes and follicles) could also be involved in persistent ZIKV infections. Further prospective studies are needed to assess the effect of ZIKV on FGT health. Instituto de Medicina Tropical 2020-03-02 /pmc/articles/PMC7051180/ /pubmed/32130356 http://dx.doi.org/10.1590/S1678-9946202062016 Text en https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Morelli, Fabrício
Souza, Raquel Pantarotto
da Cruz, Taís Elisângela
Damke, Gabrielle Marconi Zago Ferreira
Damke, Edilson
Suehiro, Tamy Tuani
da Silva, Vânia Ramos Sela
Consolaro, Marcia Edilaine Lopes
Zika virus infection in the genital tract of non-pregnant females: a systematic review
title Zika virus infection in the genital tract of non-pregnant females: a systematic review
title_full Zika virus infection in the genital tract of non-pregnant females: a systematic review
title_fullStr Zika virus infection in the genital tract of non-pregnant females: a systematic review
title_full_unstemmed Zika virus infection in the genital tract of non-pregnant females: a systematic review
title_short Zika virus infection in the genital tract of non-pregnant females: a systematic review
title_sort zika virus infection in the genital tract of non-pregnant females: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051180/
https://www.ncbi.nlm.nih.gov/pubmed/32130356
http://dx.doi.org/10.1590/S1678-9946202062016
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