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C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import

Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat expansion. However, the mechanism(s) remain unclear. Karyopherins, including importin β and its cargo adaptors, have been sh...

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Detalles Bibliográficos
Autores principales:	Hayes, Lindsey R, Duan, Lauren, Bowen, Kelly, Kalab, Petr, Rothstein, Jeffrey D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051184/ https://www.ncbi.nlm.nih.gov/pubmed/32119645 http://dx.doi.org/10.7554/eLife.51685

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