Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?

Epithelioid hemangioendothelioma (EHE) is a rare vascular malignant tumor with indolent course. Liver transplantation for local disease is the treatment of choice. In the metastatic setting there is no consensus regarding the appropriate systemic treatment. We present two cases of metastatic hepatic...

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Autores principales: Kyriazoglou, Anastasios, Koutsoukos, Konstantinos, Zagouri, Flora, Liontos, Michalis, Dimitriadis, Efthimios, Tiniakos, Dina, Dimopoulos, Meletios Athanasios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051805/
https://www.ncbi.nlm.nih.gov/pubmed/32161464
http://dx.doi.org/10.2147/TCRM.S220804
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author Kyriazoglou, Anastasios
Koutsoukos, Konstantinos
Zagouri, Flora
Liontos, Michalis
Dimitriadis, Efthimios
Tiniakos, Dina
Dimopoulos, Meletios Athanasios
author_facet Kyriazoglou, Anastasios
Koutsoukos, Konstantinos
Zagouri, Flora
Liontos, Michalis
Dimitriadis, Efthimios
Tiniakos, Dina
Dimopoulos, Meletios Athanasios
author_sort Kyriazoglou, Anastasios
collection PubMed
description Epithelioid hemangioendothelioma (EHE) is a rare vascular malignant tumor with indolent course. Liver transplantation for local disease is the treatment of choice. In the metastatic setting there is no consensus regarding the appropriate systemic treatment. We present two cases of metastatic hepatic epithelioid hemangioendothelioma (hEHE) treated with the combination of Doxorubicin and Olaratumab. Both patients showed Stable Disease (SD) as a response, after the completion of six cycles of this combination therapy.
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spelling pubmed-70518052020-03-11 Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising? Kyriazoglou, Anastasios Koutsoukos, Konstantinos Zagouri, Flora Liontos, Michalis Dimitriadis, Efthimios Tiniakos, Dina Dimopoulos, Meletios Athanasios Ther Clin Risk Manag Case Series Epithelioid hemangioendothelioma (EHE) is a rare vascular malignant tumor with indolent course. Liver transplantation for local disease is the treatment of choice. In the metastatic setting there is no consensus regarding the appropriate systemic treatment. We present two cases of metastatic hepatic epithelioid hemangioendothelioma (hEHE) treated with the combination of Doxorubicin and Olaratumab. Both patients showed Stable Disease (SD) as a response, after the completion of six cycles of this combination therapy. Dove 2020-02-27 /pmc/articles/PMC7051805/ /pubmed/32161464 http://dx.doi.org/10.2147/TCRM.S220804 Text en © 2020 Kyriazoglou et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Series
Kyriazoglou, Anastasios
Koutsoukos, Konstantinos
Zagouri, Flora
Liontos, Michalis
Dimitriadis, Efthimios
Tiniakos, Dina
Dimopoulos, Meletios Athanasios
Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?
title Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?
title_full Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?
title_fullStr Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?
title_full_unstemmed Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?
title_short Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?
title_sort metastatic hepatic epithelioid hemangioendothelioma treated with olaratumab: a falling star rising?
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051805/
https://www.ncbi.nlm.nih.gov/pubmed/32161464
http://dx.doi.org/10.2147/TCRM.S220804
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