Aconitase 2 inhibits the proliferation of MCF-7 cells promoting mitochondrial oxidative metabolism and ROS/FoxO1-mediated autophagic response

BACKGROUND: Deregulation of the tricarboxylic acid cycle (TCA) due to mutations in specific enzymes or defective aerobic metabolism is associated with tumour growth. Aconitase 2 (ACO2) participates in the TCA cycle by converting citrate to isocitrate, but no evident demonstrations of its involvement...

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Detalles Bibliográficos
Autores principales: Ciccarone, Fabio, Di Leo, Luca, Lazzarino, Giacomo, Maulucci, Giuseppe, Di Giacinto, Flavio, Tavazzi, Barbara, Ciriolo, Maria Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051954/
https://www.ncbi.nlm.nih.gov/pubmed/31819175
http://dx.doi.org/10.1038/s41416-019-0641-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051954/
https://www.ncbi.nlm.nih.gov/pubmed/31819175
http://dx.doi.org/10.1038/s41416-019-0641-0

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