Substrate Specific Inhibitor Designed against the Immunomodulator GMF-beta Reversed the Experimental Autoimmune Encephalomyelitis

The concept of substrate inhibition to prevent its phosphorylation has potential in drug discovery and is envisioned to treat the autoimmune disorder multiple sclerosis (MS). Glia maturation factor-β (GMF-β) Ser83 phosphorylation by protein kinase A (PKA) is pivotal in the activation of GMF-β-p38MAP...

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Detalles Bibliográficos
Autores principales: Vattathara, Jane Jose, Prakash, Ohm, Subhramanian, Sunitha, Satheeshkumar, Madathiparambil Kumaran, Xavier, Tessy, Anil, Meenakshi, Pillai, Gopal S., Anandakuttan, Anandkumar, Radhakrishnan, Sureshkumar, Sivanarayanan, T. B., AKK, Unni, Mohan, Chethampadi Gopi, Menon, Krishnakumar N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051966/
https://www.ncbi.nlm.nih.gov/pubmed/32123210
http://dx.doi.org/10.1038/s41598-020-60710-2

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