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Transcription and Beyond: Delineating FOXG1 Function in Cortical Development and Disorders
Forkhead Box G1 (FOXG1) is a member of the Forkhead family of genes with non-redundant roles in brain development, where alteration of this gene’s expression significantly affects the formation and function of the mammalian cerebral cortex. FOXG1 haploinsufficiency in humans is associated with promi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052011/ https://www.ncbi.nlm.nih.gov/pubmed/32158381 http://dx.doi.org/10.3389/fncel.2020.00035 |
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author | Hou, Pei-Shan hAilín, Darren Ó Vogel, Tanja Hanashima, Carina |
author_facet | Hou, Pei-Shan hAilín, Darren Ó Vogel, Tanja Hanashima, Carina |
author_sort | Hou, Pei-Shan |
collection | PubMed |
description | Forkhead Box G1 (FOXG1) is a member of the Forkhead family of genes with non-redundant roles in brain development, where alteration of this gene’s expression significantly affects the formation and function of the mammalian cerebral cortex. FOXG1 haploinsufficiency in humans is associated with prominent differences in brain size and impaired intellectual development noticeable in early childhood, while homozygous mutations are typically fatal. As such, FOXG1 has been implicated in a wide spectrum of congenital brain disorders, including the congenital variant of Rett syndrome, infantile spasms, microcephaly, autism spectrum disorder (ASD) and schizophrenia. Recent technological advances have yielded greater insight into phenotypic variations observed in FOXG1 syndrome, molecular mechanisms underlying pathogenesis of the disease, and multifaceted roles of FOXG1 expression. In this review, we explore the emerging mechanisms of FOXG1 in a range of transcriptional to posttranscriptional events in order to evolve our current view of how a single transcription factor governs the assembly of an elaborate cortical circuit responsible for higher cognitive functions and neurological disorders. |
format | Online Article Text |
id | pubmed-7052011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70520112020-03-10 Transcription and Beyond: Delineating FOXG1 Function in Cortical Development and Disorders Hou, Pei-Shan hAilín, Darren Ó Vogel, Tanja Hanashima, Carina Front Cell Neurosci Cellular Neuroscience Forkhead Box G1 (FOXG1) is a member of the Forkhead family of genes with non-redundant roles in brain development, where alteration of this gene’s expression significantly affects the formation and function of the mammalian cerebral cortex. FOXG1 haploinsufficiency in humans is associated with prominent differences in brain size and impaired intellectual development noticeable in early childhood, while homozygous mutations are typically fatal. As such, FOXG1 has been implicated in a wide spectrum of congenital brain disorders, including the congenital variant of Rett syndrome, infantile spasms, microcephaly, autism spectrum disorder (ASD) and schizophrenia. Recent technological advances have yielded greater insight into phenotypic variations observed in FOXG1 syndrome, molecular mechanisms underlying pathogenesis of the disease, and multifaceted roles of FOXG1 expression. In this review, we explore the emerging mechanisms of FOXG1 in a range of transcriptional to posttranscriptional events in order to evolve our current view of how a single transcription factor governs the assembly of an elaborate cortical circuit responsible for higher cognitive functions and neurological disorders. Frontiers Media S.A. 2020-02-25 /pmc/articles/PMC7052011/ /pubmed/32158381 http://dx.doi.org/10.3389/fncel.2020.00035 Text en Copyright © 2020 Hou, Ó hAilín, Vogel and Hanashima. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular Neuroscience Hou, Pei-Shan hAilín, Darren Ó Vogel, Tanja Hanashima, Carina Transcription and Beyond: Delineating FOXG1 Function in Cortical Development and Disorders |
title | Transcription and Beyond: Delineating FOXG1 Function in Cortical Development and Disorders |
title_full | Transcription and Beyond: Delineating FOXG1 Function in Cortical Development and Disorders |
title_fullStr | Transcription and Beyond: Delineating FOXG1 Function in Cortical Development and Disorders |
title_full_unstemmed | Transcription and Beyond: Delineating FOXG1 Function in Cortical Development and Disorders |
title_short | Transcription and Beyond: Delineating FOXG1 Function in Cortical Development and Disorders |
title_sort | transcription and beyond: delineating foxg1 function in cortical development and disorders |
topic | Cellular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052011/ https://www.ncbi.nlm.nih.gov/pubmed/32158381 http://dx.doi.org/10.3389/fncel.2020.00035 |
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