Cargando…

Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling

Linear ubiquitination is a critical regulator of inflammatory signaling pathways. However, linearly ubiquitinated substrates and the biological significance of linear ubiquitination is incompletely understood. Here, we show that STAT1 has linear ubiquitination at Lys511 and Lys652 residues in intact...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zuo, Yibo, Feng, Qian, Jin, Lincong, Huang, Fan, Miao, Ying, Liu, Jin, Xu, Ying, Chen, Xiangjie, Zhang, Hongguang, Guo, Tingting, Yuan, Yukang, Zhang, Liting, Wang, Jun, Zheng, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052135/ https://www.ncbi.nlm.nih.gov/pubmed/32123171 http://dx.doi.org/10.1038/s41467-020-14948-z

Ejemplares similares

USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity
por: Liu, Jin, et al.
Publicado: (2020)

Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus
por: Ren, Ying, et al.
Publicado: (2016)

LATS1 is a central signal transmitter for achieving full type-I interferon activity
por: Zuo, Yibo, et al.
Publicado: (2022)

Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1
por: Zhang, Hong-Guang, et al.
Publicado: (2020)

Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome
por: Zhang, Liting, et al.
Publicado: (2018)

Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis
por: Zhang, Hong-Guang, et al.
Publicado: (2022)

Ubiquitin E3 ligase SPOP is a host negative regulator of enterovirus 71-encoded 2A protease
por: Zang, Lichao, et al.
Publicado: (2023)

Cycloheximide (CHX) Chase Assay to Examine Protein Half-life
por: Miao, Ying, et al.
Publicado: (2023)

The tyrosine kinase c-Abl potentiates interferon-mediated antiviral immunity by STAT1 phosphorylation
por: Liu, Hainan, et al.
Publicado: (2021)

HOIP modulates the stability of GPx4 by linear ubiquitination
por: Dong, Kangyun, et al.
Publicado: (2022)

Site-specific ubiquitination exposes a linear motif to promote interferon-α receptor endocytosis
por: Kumar, K.G. Suresh, et al.
Publicado: (2007)

ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination
por: Zhang, Ying, et al.
Publicado: (2018)

β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling
por: Liu, Jin, et al.
Publicado: (2018)

Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway
por: Yu, Jung-Sheng, et al.
Publicado: (2017)

The Ubiquitin Ligase TRAF6 Negatively Regulates the JAK-STAT Signaling Pathway by Binding to STAT3 and Mediating Its Ubiquitination
por: Wei, Juncheng, et al.
Publicado: (2012)

An Integrated View of Deubiquitinating Enzymes Involved in Type I Interferon Signaling, Host Defense and Antiviral Activities
por: Qian, Guanghui, et al.
Publicado: (2021)

Regulation of Cellular Antiviral Signaling by Modifications of Ubiquitin and Ubiquitin-like Molecules
por: Li, Kang, et al.
Publicado: (2018)

Interferons: Signaling, antiviral and viral evasion
por: Bonjardim, Cláudio A., et al.
Publicado: (2009)

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response
por: Blanc, Mathieu, et al.
Publicado: (2013)

Interferon-α-induced CD100 on naïve CD8(+) T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction
por: Li, Bing Jie, et al.
Publicado: (2017)

Linear ubiquitination in immunity
por: Shimizu, Yutaka, et al.
Publicado: (2015)

A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma
por: Du, Xianli, et al.
Publicado: (2023)

Antiviral activities of interferons
por: Stewart, William E., et al.
Publicado: (1979)

Interferon Independent Non-Canonical STAT Activation and Virus Induced Inflammation
por: Nan, Yuchen, et al.
Publicado: (2018)

Interleukin-6 and Interferon-α Signaling via JAK1–STAT Differentially Regulate Oncolytic versus Cytoprotective Antiviral States
por: Danziger, Oded, et al.
Publicado: (2018)

Interferon-γ-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1
por: Ning, Yun-Jia, et al.
Publicado: (2019)

The regulation of antiviral activity of interferon epsilon
por: Zhao, Fu-Rong, et al.
Publicado: (2022)

5-Hydroxymethylfurfural Enhances the Antiviral Immune Response in Macrophages through the Modulation of RIG-I-Mediated Interferon Production and the JAK/STAT Signaling Pathway
por: Zou, Han, et al.
Publicado: (2021)

The regulation of inflammation by interferons and their STATs
por: Rauch, Isabella, et al.
Publicado: (2013)

Antiviral effects of interferon-stimulated genes in bats
por: Zhang, Dan, et al.
Publicado: (2023)

Interferon-inducible antiviral effectors
por: Sadler, Anthony J., et al.
Publicado: (2008)

Antiviral defense: interferons and beyond
por: Stetson, Daniel B., et al.
Publicado: (2006)

Avian Interferons and Their Antiviral Effectors
por: Santhakumar, Diwakar, et al.
Publicado: (2017)

Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathway
por: Yang, Qi, et al.
Publicado: (2020)

Cloning, expression, and antiviral activity of interferon β from the Chinese microbat, Myotis davidii
por: Liang, Ying-Zi, et al.
Publicado: (2015)

Ubiquitination in Scleroderma Fibrosis and Its Treatment
por: Long, Ying, et al.
Publicado: (2018)

Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway
por: Au-Yeung, Nancy, et al.
Publicado: (2013)

DEMETER plant DNA demethylase induces antiviral response by interferon signalling in animal cells
por: Mok, Young Geun, et al.
Publicado: (2017)

Fish TRIM8 exerts antiviral roles through regulation of the proinflammatory factors and interferon signaling
por: Huang, Youhua, et al.
Publicado: (2016)

Cloning, expression and antiviral activity of mink alpha-interferons
por: Zhang, Hai-ling, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_2gintdprk3ncpjujicsefo2qt0