Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade

Cyt1Aa is the one of four crystalline protoxins produced by mosquitocidal bacterium Bacillus thuringiensis israelensis (Bti) that has been shown to delay the evolution of insect resistance in the field. Limiting our understanding of Bti efficacy and the path to improved toxicity and spectrum has bee...

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Detalles Bibliográficos
Autores principales: Tetreau, Guillaume, Banneville, Anne-Sophie, Andreeva, Elena A., Brewster, Aaron S., Hunter, Mark S., Sierra, Raymond G., Teulon, Jean-Marie, Young, Iris D., Burke, Niamh, Grünewald, Tilman A., Beaudouin, Joël, Snigireva, Irina, Fernandez-Luna, Maria Teresa, Burt, Alister, Park, Hyun-Woo, Signor, Luca, Bafna, Jayesh A., Sadir, Rabia, Fenel, Daphna, Boeri-Erba, Elisabetta, Bacia, Maria, Zala, Ninon, Laporte, Frédéric, Després, Laurence, Weik, Martin, Boutet, Sébastien, Rosenthal, Martin, Coquelle, Nicolas, Burghammer, Manfred, Cascio, Duilio, Sawaya, Michael R., Winterhalter, Mathias, Gratton, Enrico, Gutsche, Irina, Federici, Brian, Pellequer, Jean-Luc, Sauter, Nicholas K., Colletier, Jacques-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052140/
https://www.ncbi.nlm.nih.gov/pubmed/32123169
http://dx.doi.org/10.1038/s41467-020-14894-w

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