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Complex approach for analysis of snake venom α-neurotoxins binding to HAP, the high-affinity peptide

Snake venom α-neurotoxins, invaluable pharmacological tools, bind with high affinity to distinct subtypes of nicotinic acetylcholine receptor. The combinatorial high-affinity peptide (HAP), homologous to the C-loop of α1 and α7 nAChR subunits, binds biotinylated α-bungarotoxin (αBgt) with nanomolar...

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Detalles Bibliográficos
Autores principales:	Kudryavtsev, Denis S., Tabakmakher, Valentin М., Budylin, Gleb S., Egorova, Natalia S., Efremov, Roman G., Ivanov, Igor A., Belukhina, Svetlana Yu., Jegorov, Artjom V., Kasheverov, Igor E., Kryukova, Elena V., Shelukhina, Irina V., Shirshin, Evgeny A., Zhdanova, Nadezhda G., Zhmak, Maxim N., Tsetlin, Victor I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052197/ https://www.ncbi.nlm.nih.gov/pubmed/32123252 http://dx.doi.org/10.1038/s41598-020-60768-y

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