Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells

There is mounting evidence of androgen receptor signaling inducing genome instability and changing DNA repair capacity in prostate cancer cells. Expression of genes associated with base excision repair (BER) is increased with prostate cancer progression and correlates with poor prognosis. Poly(ADP-r...

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Detalles Bibliográficos
Autores principales: Zhang, Manqi, Lai, Yanhao, Vasquez, Judy L., James, Dominic I., Smith, Kate M., Waddell, Ian D., Ogilvie, Donald J., Liu, Yuan, Agoulnik, Irina U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052214/
https://www.ncbi.nlm.nih.gov/pubmed/32123273
http://dx.doi.org/10.1038/s41598-020-60849-y

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