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Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance
BACKGROUND: Ferroptosis is an iron-dependent, lipid peroxide-mediated cell death that may be exploited to selective elimination of damaged and malignant cells. Recent studies have identified that small-molecule erastin specifically inhibits transmembrane cystine–glutamate antiporter system x(c)(−),...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052275/ https://www.ncbi.nlm.nih.gov/pubmed/31819185 http://dx.doi.org/10.1038/s41416-019-0660-x |