Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells

The pathogenesis of Huntington’s disease (HD), an inherited progressive neurodegenerative disease, is highly associated with the cytotoxicity-inducing mutant huntingtin (mHtt) protein. Emerging evidence indicates that autophagy plays a pivotal role in degrading aggregated proteins such as mHtt to en...

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Detalles Bibliográficos
Autores principales: Sun, Yueshan, Jiang, Xueqin, Pan, Rong, Zhou, Xiaogang, Qin, Dalian, Xiong, Rui, Wang, Yiling, Qiu, Wenqiao, Wu, Anguo, Wu, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052340/
https://www.ncbi.nlm.nih.gov/pubmed/32158393
http://dx.doi.org/10.3389/fphar.2020.00116

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