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Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer
BACKGROUND: Systemic inflammation and nutrition status play an important role in cancer metastasis. The combined index of hemoglobin, albumin, lymphocyte, and platelet (HALP), consisting of haemoglobin, albumin, lymphocytes, and platelets, is considered as a novel marker to reflect both systemic inf...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052532/ https://www.ncbi.nlm.nih.gov/pubmed/32148380 http://dx.doi.org/10.3748/wjg.v26.i8.828 |
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author | Xu, Shuai-Shuai Li, Shuo Xu, Hua-Xiang Li, Hao Wu, Chun-Tao Wang, Wen-Quan Gao, He-Li Jiang, Wang Zhang, Wu-Hu Li, Tian-Jiao Ni, Quan-Xing Liu, Liang Yu, Xian-Jun |
author_facet | Xu, Shuai-Shuai Li, Shuo Xu, Hua-Xiang Li, Hao Wu, Chun-Tao Wang, Wen-Quan Gao, He-Li Jiang, Wang Zhang, Wu-Hu Li, Tian-Jiao Ni, Quan-Xing Liu, Liang Yu, Xian-Jun |
author_sort | Xu, Shuai-Shuai |
collection | PubMed |
description | BACKGROUND: Systemic inflammation and nutrition status play an important role in cancer metastasis. The combined index of hemoglobin, albumin, lymphocyte, and platelet (HALP), consisting of haemoglobin, albumin, lymphocytes, and platelets, is considered as a novel marker to reflect both systemic inflammation and nutrition status. However, no studies have investigated the relationship between HALP and survival of patients with pancreatic cancer following radical resection. AIM: To evaluate the prognostic value of preoperative HALP in pancreatic cancer patients. METHODS: The preoperative serum levels of hemoglobin, albumin, lymphocyte counts, and platelet counts were routinely detected in 582 pancreatic adenocarcinoma patients who underwent radical resection. The relationship between postoperative survival and the preoperative level of HALP was investigated. RESULTS: Low levels of HALP were significantly associated with lymph node metastasis (P = 0.002), poor tumor differentiation (P = 0.032), high TNM stage (P = 0.008), female patients (P = 0.005) and tumor location in the head of the pancreas (P < 0.001). Low levels of HALP were associated with early recurrence [7.3 mo vs 16.3 mo, P < 0.001 for recurrence-free survival (RFS)] and short survival [11.5 mo vs 23.6 mo, P < 0.001 for overall survival (OS)] in patients with resected pancreatic adenocarcinoma. A low level of HALP was an independent risk factor for early recurrence and short survival irrespective of sex and tumor location. CONCLUSION: Low levels of HALP may be a significant risk factor for RFS and OS in patients with resected pancreatic cancer. |
format | Online Article Text |
id | pubmed-7052532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-70525322020-03-06 Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer Xu, Shuai-Shuai Li, Shuo Xu, Hua-Xiang Li, Hao Wu, Chun-Tao Wang, Wen-Quan Gao, He-Li Jiang, Wang Zhang, Wu-Hu Li, Tian-Jiao Ni, Quan-Xing Liu, Liang Yu, Xian-Jun World J Gastroenterol Retrospective Study BACKGROUND: Systemic inflammation and nutrition status play an important role in cancer metastasis. The combined index of hemoglobin, albumin, lymphocyte, and platelet (HALP), consisting of haemoglobin, albumin, lymphocytes, and platelets, is considered as a novel marker to reflect both systemic inflammation and nutrition status. However, no studies have investigated the relationship between HALP and survival of patients with pancreatic cancer following radical resection. AIM: To evaluate the prognostic value of preoperative HALP in pancreatic cancer patients. METHODS: The preoperative serum levels of hemoglobin, albumin, lymphocyte counts, and platelet counts were routinely detected in 582 pancreatic adenocarcinoma patients who underwent radical resection. The relationship between postoperative survival and the preoperative level of HALP was investigated. RESULTS: Low levels of HALP were significantly associated with lymph node metastasis (P = 0.002), poor tumor differentiation (P = 0.032), high TNM stage (P = 0.008), female patients (P = 0.005) and tumor location in the head of the pancreas (P < 0.001). Low levels of HALP were associated with early recurrence [7.3 mo vs 16.3 mo, P < 0.001 for recurrence-free survival (RFS)] and short survival [11.5 mo vs 23.6 mo, P < 0.001 for overall survival (OS)] in patients with resected pancreatic adenocarcinoma. A low level of HALP was an independent risk factor for early recurrence and short survival irrespective of sex and tumor location. CONCLUSION: Low levels of HALP may be a significant risk factor for RFS and OS in patients with resected pancreatic cancer. Baishideng Publishing Group Inc 2020-02-28 2020-02-28 /pmc/articles/PMC7052532/ /pubmed/32148380 http://dx.doi.org/10.3748/wjg.v26.i8.828 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Retrospective Study Xu, Shuai-Shuai Li, Shuo Xu, Hua-Xiang Li, Hao Wu, Chun-Tao Wang, Wen-Quan Gao, He-Li Jiang, Wang Zhang, Wu-Hu Li, Tian-Jiao Ni, Quan-Xing Liu, Liang Yu, Xian-Jun Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer |
title | Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer |
title_full | Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer |
title_fullStr | Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer |
title_full_unstemmed | Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer |
title_short | Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer |
title_sort | haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer |
topic | Retrospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052532/ https://www.ncbi.nlm.nih.gov/pubmed/32148380 http://dx.doi.org/10.3748/wjg.v26.i8.828 |
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