Microbiome Restoration by RBX2660 Does Not Preclude Recurrence of Multidrug-Resistant Urinary Tract Infection Following Subsequent Antibiotic Exposure: A Case Report

A 62-year-old woman received RBX2660, an investigational microbiome restoration therapeutic, for recurrent multidrug-resistant (MDR) urinary tract infection (UTI). RBX2660 increased gut microbiome diversity but did not eliminate uropathogen carriage, and MDR UTI recurred after subsequent antibiotic...

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Autores principales: Keen, Eric C, Tasoff, Preston, Hink, Tiffany, Reske, Kimberly A, Burnham, Carey-Ann D, Dantas, Gautam, Kwon, Jennie H, Dubberke, Erik R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report (Fast track - FIDSA members only)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052748/
https://www.ncbi.nlm.nih.gov/pubmed/32154322
http://dx.doi.org/10.1093/ofid/ofaa042
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author Keen, Eric C
Tasoff, Preston
Hink, Tiffany
Reske, Kimberly A
Burnham, Carey-Ann D
Dantas, Gautam
Kwon, Jennie H
Dubberke, Erik R
author_facet Keen, Eric C
Tasoff, Preston
Hink, Tiffany
Reske, Kimberly A
Burnham, Carey-Ann D
Dantas, Gautam
Kwon, Jennie H
Dubberke, Erik R
author_sort Keen, Eric C
collection PubMed
description A 62-year-old woman received RBX2660, an investigational microbiome restoration therapeutic, for recurrent multidrug-resistant (MDR) urinary tract infection (UTI). RBX2660 increased gut microbiome diversity but did not eliminate uropathogen carriage, and MDR UTI recurred after subsequent antibiotic exposure. Thus, restoration of microbiome diversity does not preclude disease recurrence by residual MDR pathogens.
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spelling pubmed-70527482020-03-09 Microbiome Restoration by RBX2660 Does Not Preclude Recurrence of Multidrug-Resistant Urinary Tract Infection Following Subsequent Antibiotic Exposure: A Case Report Keen, Eric C Tasoff, Preston Hink, Tiffany Reske, Kimberly A Burnham, Carey-Ann D Dantas, Gautam Kwon, Jennie H Dubberke, Erik R Open Forum Infect Dis Brief Report (Fast track - FIDSA members only) A 62-year-old woman received RBX2660, an investigational microbiome restoration therapeutic, for recurrent multidrug-resistant (MDR) urinary tract infection (UTI). RBX2660 increased gut microbiome diversity but did not eliminate uropathogen carriage, and MDR UTI recurred after subsequent antibiotic exposure. Thus, restoration of microbiome diversity does not preclude disease recurrence by residual MDR pathogens. Oxford University Press 2020-02-11 /pmc/articles/PMC7052748/ /pubmed/32154322 http://dx.doi.org/10.1093/ofid/ofaa042 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report (Fast track - FIDSA members only)
Keen, Eric C
Tasoff, Preston
Hink, Tiffany
Reske, Kimberly A
Burnham, Carey-Ann D
Dantas, Gautam
Kwon, Jennie H
Dubberke, Erik R
Microbiome Restoration by RBX2660 Does Not Preclude Recurrence of Multidrug-Resistant Urinary Tract Infection Following Subsequent Antibiotic Exposure: A Case Report
title Microbiome Restoration by RBX2660 Does Not Preclude Recurrence of Multidrug-Resistant Urinary Tract Infection Following Subsequent Antibiotic Exposure: A Case Report
title_full Microbiome Restoration by RBX2660 Does Not Preclude Recurrence of Multidrug-Resistant Urinary Tract Infection Following Subsequent Antibiotic Exposure: A Case Report
title_fullStr Microbiome Restoration by RBX2660 Does Not Preclude Recurrence of Multidrug-Resistant Urinary Tract Infection Following Subsequent Antibiotic Exposure: A Case Report
title_full_unstemmed Microbiome Restoration by RBX2660 Does Not Preclude Recurrence of Multidrug-Resistant Urinary Tract Infection Following Subsequent Antibiotic Exposure: A Case Report
title_short Microbiome Restoration by RBX2660 Does Not Preclude Recurrence of Multidrug-Resistant Urinary Tract Infection Following Subsequent Antibiotic Exposure: A Case Report
title_sort microbiome restoration by rbx2660 does not preclude recurrence of multidrug-resistant urinary tract infection following subsequent antibiotic exposure: a case report
topic Brief Report (Fast track - FIDSA members only)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052748/
https://www.ncbi.nlm.nih.gov/pubmed/32154322
http://dx.doi.org/10.1093/ofid/ofaa042
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