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Partners in Crime: NGF and BDNF in Visceral Dysfunction
Neurotrophins (NTs), particularly Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF), have attracted increasing attention in the context of visceral function for some years. Here, we examined the current literature and presented a thorough review of the subject. After initial stu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052822/ https://www.ncbi.nlm.nih.gov/pubmed/31204623 http://dx.doi.org/10.2174/1570159X17666190617095844 |
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author | Coelho, Ana Oliveira, Raquel Antunes-Lopes, Tiago Cruz, Célia Duarte |
author_facet | Coelho, Ana Oliveira, Raquel Antunes-Lopes, Tiago Cruz, Célia Duarte |
author_sort | Coelho, Ana |
collection | PubMed |
description | Neurotrophins (NTs), particularly Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF), have attracted increasing attention in the context of visceral function for some years. Here, we examined the current literature and presented a thorough review of the subject. After initial studies linking of NGF to cystitis, it is now well-established that this neurotrophin (NT) is a key modulator of bladder pathologies, including Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS. NGF is upregulated in bladder tissue and its blockade results in major improvements on urodynamic parameters and pain. Further studies expanded showed that NGF is also an intervenient in other visceral dysfunctions such as endometriosis and Irritable Bowel Syndrome (IBS). More recently, BDNF was also shown to play an important role in the same visceral dysfunctions, suggesting that both NTs are determinant factors in visceral pathophysiological mechanisms. Manipulation of NGF and BDNF improves visceral function and reduce pain, suggesting that clinical modulation of these NTs may be important; however, much is still to be investigated before this step is taken. Another active area of research is centered on urinary NGF and BDNF. Several studies show that both NTs can be found in the urine of patients with visceral dysfunction in much higher concentration than in healthy individuals, suggesting that they could be used as potential biomarkers. However, there are still technical difficulties to be overcome, including the lack of a large multicentre placebo-controlled studies to prove the relevance of urinary NTs as clinical biomarkers. |
format | Online Article Text |
id | pubmed-7052822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-70528222020-05-01 Partners in Crime: NGF and BDNF in Visceral Dysfunction Coelho, Ana Oliveira, Raquel Antunes-Lopes, Tiago Cruz, Célia Duarte Curr Neuropharmacol Article Neurotrophins (NTs), particularly Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF), have attracted increasing attention in the context of visceral function for some years. Here, we examined the current literature and presented a thorough review of the subject. After initial studies linking of NGF to cystitis, it is now well-established that this neurotrophin (NT) is a key modulator of bladder pathologies, including Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS. NGF is upregulated in bladder tissue and its blockade results in major improvements on urodynamic parameters and pain. Further studies expanded showed that NGF is also an intervenient in other visceral dysfunctions such as endometriosis and Irritable Bowel Syndrome (IBS). More recently, BDNF was also shown to play an important role in the same visceral dysfunctions, suggesting that both NTs are determinant factors in visceral pathophysiological mechanisms. Manipulation of NGF and BDNF improves visceral function and reduce pain, suggesting that clinical modulation of these NTs may be important; however, much is still to be investigated before this step is taken. Another active area of research is centered on urinary NGF and BDNF. Several studies show that both NTs can be found in the urine of patients with visceral dysfunction in much higher concentration than in healthy individuals, suggesting that they could be used as potential biomarkers. However, there are still technical difficulties to be overcome, including the lack of a large multicentre placebo-controlled studies to prove the relevance of urinary NTs as clinical biomarkers. Bentham Science Publishers 2019-11 2019-11 /pmc/articles/PMC7052822/ /pubmed/31204623 http://dx.doi.org/10.2174/1570159X17666190617095844 Text en © 2019 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Coelho, Ana Oliveira, Raquel Antunes-Lopes, Tiago Cruz, Célia Duarte Partners in Crime: NGF and BDNF in Visceral Dysfunction |
title | Partners in Crime: NGF and BDNF in Visceral Dysfunction |
title_full | Partners in Crime: NGF and BDNF in Visceral Dysfunction |
title_fullStr | Partners in Crime: NGF and BDNF in Visceral Dysfunction |
title_full_unstemmed | Partners in Crime: NGF and BDNF in Visceral Dysfunction |
title_short | Partners in Crime: NGF and BDNF in Visceral Dysfunction |
title_sort | partners in crime: ngf and bdnf in visceral dysfunction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052822/ https://www.ncbi.nlm.nih.gov/pubmed/31204623 http://dx.doi.org/10.2174/1570159X17666190617095844 |
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