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Proteoglycan 4 predicts tribological properties of repaired cartilage tissue
Purpose: One of the essential requirements in maintaining the normal joint motor function is the perfect tribological property of the articular cartilage. Many cartilage regeneration strategies have been developed for treatment in early stages of osteoarthritis, but there is little information on ho...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052906/ https://www.ncbi.nlm.nih.gov/pubmed/32194818 http://dx.doi.org/10.7150/thno.39386 |
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author | Qiao, Zhiguang Xin, Mei Wang, Ling Li, Huiwu Wang, Chengtao Wang, Liao Tang, Tingting Zhu, Bangshang Huang, Gang Wang, You Zheng, Minghao Dai, Kerong |
author_facet | Qiao, Zhiguang Xin, Mei Wang, Ling Li, Huiwu Wang, Chengtao Wang, Liao Tang, Tingting Zhu, Bangshang Huang, Gang Wang, You Zheng, Minghao Dai, Kerong |
author_sort | Qiao, Zhiguang |
collection | PubMed |
description | Purpose: One of the essential requirements in maintaining the normal joint motor function is the perfect tribological property of the articular cartilage. Many cartilage regeneration strategies have been developed for treatment in early stages of osteoarthritis, but there is little information on how repaired articular cartilage regains durability. The identification of biomarkers that can predict wear resistant property is critical to advancing the success of cartilage regeneration therapies. Proteoglycan 4 (PRG4) is a macromolecule distributing on the chondrocyte surface that contributes to lubrication. In this study, we investigate if PRG4 expression is associated with tribological properties of regenerated cartilage, and is able to predict its wear resistant status. Methods: Two different strategies including bone marrow enrichment plus microfracture (B/BME-MFX) and microfracture alone (B-MFX) of cartilage repair in sheep were used. PRG4 expression and a series of tribological parameters on regenerated cartilage were rigorously examined and compared. Results: Highly and continuously expression of PRG4 in regenerated cartilage surface was negatively correlated with each tribological parameter (P<0.0001, respectively). Multivariate analysis showed that PRG4 expression was the key predictor that contributed to the promotion of cartilage wear resistance. Conclusion: Higher PRG4 expression in regenerated cartilage is significantly associated with wear resistance improvement. PRG4 may be useful for predicting the wear resistant status of regenerated cartilage and determining the optimal cartilage repair strategy. |
format | Online Article Text |
id | pubmed-7052906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-70529062020-03-19 Proteoglycan 4 predicts tribological properties of repaired cartilage tissue Qiao, Zhiguang Xin, Mei Wang, Ling Li, Huiwu Wang, Chengtao Wang, Liao Tang, Tingting Zhu, Bangshang Huang, Gang Wang, You Zheng, Minghao Dai, Kerong Theranostics Research Paper Purpose: One of the essential requirements in maintaining the normal joint motor function is the perfect tribological property of the articular cartilage. Many cartilage regeneration strategies have been developed for treatment in early stages of osteoarthritis, but there is little information on how repaired articular cartilage regains durability. The identification of biomarkers that can predict wear resistant property is critical to advancing the success of cartilage regeneration therapies. Proteoglycan 4 (PRG4) is a macromolecule distributing on the chondrocyte surface that contributes to lubrication. In this study, we investigate if PRG4 expression is associated with tribological properties of regenerated cartilage, and is able to predict its wear resistant status. Methods: Two different strategies including bone marrow enrichment plus microfracture (B/BME-MFX) and microfracture alone (B-MFX) of cartilage repair in sheep were used. PRG4 expression and a series of tribological parameters on regenerated cartilage were rigorously examined and compared. Results: Highly and continuously expression of PRG4 in regenerated cartilage surface was negatively correlated with each tribological parameter (P<0.0001, respectively). Multivariate analysis showed that PRG4 expression was the key predictor that contributed to the promotion of cartilage wear resistance. Conclusion: Higher PRG4 expression in regenerated cartilage is significantly associated with wear resistance improvement. PRG4 may be useful for predicting the wear resistant status of regenerated cartilage and determining the optimal cartilage repair strategy. Ivyspring International Publisher 2020-01-22 /pmc/articles/PMC7052906/ /pubmed/32194818 http://dx.doi.org/10.7150/thno.39386 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Qiao, Zhiguang Xin, Mei Wang, Ling Li, Huiwu Wang, Chengtao Wang, Liao Tang, Tingting Zhu, Bangshang Huang, Gang Wang, You Zheng, Minghao Dai, Kerong Proteoglycan 4 predicts tribological properties of repaired cartilage tissue |
title | Proteoglycan 4 predicts tribological properties of repaired cartilage tissue |
title_full | Proteoglycan 4 predicts tribological properties of repaired cartilage tissue |
title_fullStr | Proteoglycan 4 predicts tribological properties of repaired cartilage tissue |
title_full_unstemmed | Proteoglycan 4 predicts tribological properties of repaired cartilage tissue |
title_short | Proteoglycan 4 predicts tribological properties of repaired cartilage tissue |
title_sort | proteoglycan 4 predicts tribological properties of repaired cartilage tissue |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052906/ https://www.ncbi.nlm.nih.gov/pubmed/32194818 http://dx.doi.org/10.7150/thno.39386 |
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