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Proteoglycan 4 predicts tribological properties of repaired cartilage tissue

Purpose: One of the essential requirements in maintaining the normal joint motor function is the perfect tribological property of the articular cartilage. Many cartilage regeneration strategies have been developed for treatment in early stages of osteoarthritis, but there is little information on ho...

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Autores principales: Qiao, Zhiguang, Xin, Mei, Wang, Ling, Li, Huiwu, Wang, Chengtao, Wang, Liao, Tang, Tingting, Zhu, Bangshang, Huang, Gang, Wang, You, Zheng, Minghao, Dai, Kerong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052906/
https://www.ncbi.nlm.nih.gov/pubmed/32194818
http://dx.doi.org/10.7150/thno.39386
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author Qiao, Zhiguang
Xin, Mei
Wang, Ling
Li, Huiwu
Wang, Chengtao
Wang, Liao
Tang, Tingting
Zhu, Bangshang
Huang, Gang
Wang, You
Zheng, Minghao
Dai, Kerong
author_facet Qiao, Zhiguang
Xin, Mei
Wang, Ling
Li, Huiwu
Wang, Chengtao
Wang, Liao
Tang, Tingting
Zhu, Bangshang
Huang, Gang
Wang, You
Zheng, Minghao
Dai, Kerong
author_sort Qiao, Zhiguang
collection PubMed
description Purpose: One of the essential requirements in maintaining the normal joint motor function is the perfect tribological property of the articular cartilage. Many cartilage regeneration strategies have been developed for treatment in early stages of osteoarthritis, but there is little information on how repaired articular cartilage regains durability. The identification of biomarkers that can predict wear resistant property is critical to advancing the success of cartilage regeneration therapies. Proteoglycan 4 (PRG4) is a macromolecule distributing on the chondrocyte surface that contributes to lubrication. In this study, we investigate if PRG4 expression is associated with tribological properties of regenerated cartilage, and is able to predict its wear resistant status. Methods: Two different strategies including bone marrow enrichment plus microfracture (B/BME-MFX) and microfracture alone (B-MFX) of cartilage repair in sheep were used. PRG4 expression and a series of tribological parameters on regenerated cartilage were rigorously examined and compared. Results: Highly and continuously expression of PRG4 in regenerated cartilage surface was negatively correlated with each tribological parameter (P<0.0001, respectively). Multivariate analysis showed that PRG4 expression was the key predictor that contributed to the promotion of cartilage wear resistance. Conclusion: Higher PRG4 expression in regenerated cartilage is significantly associated with wear resistance improvement. PRG4 may be useful for predicting the wear resistant status of regenerated cartilage and determining the optimal cartilage repair strategy.
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spelling pubmed-70529062020-03-19 Proteoglycan 4 predicts tribological properties of repaired cartilage tissue Qiao, Zhiguang Xin, Mei Wang, Ling Li, Huiwu Wang, Chengtao Wang, Liao Tang, Tingting Zhu, Bangshang Huang, Gang Wang, You Zheng, Minghao Dai, Kerong Theranostics Research Paper Purpose: One of the essential requirements in maintaining the normal joint motor function is the perfect tribological property of the articular cartilage. Many cartilage regeneration strategies have been developed for treatment in early stages of osteoarthritis, but there is little information on how repaired articular cartilage regains durability. The identification of biomarkers that can predict wear resistant property is critical to advancing the success of cartilage regeneration therapies. Proteoglycan 4 (PRG4) is a macromolecule distributing on the chondrocyte surface that contributes to lubrication. In this study, we investigate if PRG4 expression is associated with tribological properties of regenerated cartilage, and is able to predict its wear resistant status. Methods: Two different strategies including bone marrow enrichment plus microfracture (B/BME-MFX) and microfracture alone (B-MFX) of cartilage repair in sheep were used. PRG4 expression and a series of tribological parameters on regenerated cartilage were rigorously examined and compared. Results: Highly and continuously expression of PRG4 in regenerated cartilage surface was negatively correlated with each tribological parameter (P<0.0001, respectively). Multivariate analysis showed that PRG4 expression was the key predictor that contributed to the promotion of cartilage wear resistance. Conclusion: Higher PRG4 expression in regenerated cartilage is significantly associated with wear resistance improvement. PRG4 may be useful for predicting the wear resistant status of regenerated cartilage and determining the optimal cartilage repair strategy. Ivyspring International Publisher 2020-01-22 /pmc/articles/PMC7052906/ /pubmed/32194818 http://dx.doi.org/10.7150/thno.39386 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Qiao, Zhiguang
Xin, Mei
Wang, Ling
Li, Huiwu
Wang, Chengtao
Wang, Liao
Tang, Tingting
Zhu, Bangshang
Huang, Gang
Wang, You
Zheng, Minghao
Dai, Kerong
Proteoglycan 4 predicts tribological properties of repaired cartilage tissue
title Proteoglycan 4 predicts tribological properties of repaired cartilage tissue
title_full Proteoglycan 4 predicts tribological properties of repaired cartilage tissue
title_fullStr Proteoglycan 4 predicts tribological properties of repaired cartilage tissue
title_full_unstemmed Proteoglycan 4 predicts tribological properties of repaired cartilage tissue
title_short Proteoglycan 4 predicts tribological properties of repaired cartilage tissue
title_sort proteoglycan 4 predicts tribological properties of repaired cartilage tissue
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052906/
https://www.ncbi.nlm.nih.gov/pubmed/32194818
http://dx.doi.org/10.7150/thno.39386
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