Epstein barr virus encodes miRNAs to assist host immune escape

Epstein-barr virus (EBV) is a definite tumorigenic virus, which can form life-long latency in the host, which is difficult to be recognized and completely eliminated by the immune system. It is closely related to the occurrence and development of nasopharyngeal cancer, gastric cancer and various typ...

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Detalles Bibliográficos
Autores principales: Li, Weiming, He, Cong, Wu, Jiayi, Yang, Dazhi, Yi, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052931/
https://www.ncbi.nlm.nih.gov/pubmed/32127936
http://dx.doi.org/10.7150/jca.42498
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author Li, Weiming
He, Cong
Wu, Jiayi
Yang, Dazhi
Yi, Weihong
author_facet Li, Weiming
He, Cong
Wu, Jiayi
Yang, Dazhi
Yi, Weihong
author_sort Li, Weiming
collection PubMed
description Epstein-barr virus (EBV) is a definite tumorigenic virus, which can form life-long latency in the host, which is difficult to be recognized and completely eliminated by the immune system. It is closely related to the occurrence and development of nasopharyngeal cancer, gastric cancer and various types of lymphoma. At present, a total of 44 Epstein-barr virus-encoded microRNAs (EBV miRNAs) have been found. In response to the immune system of the body, EBV miRNAs can inhibit the expression and presentation of viral antigens, inhibit immune activation and immunotoxicity, assisting host cells to escape from immunity, and providing conditions for further immortalized tumorigenesis of the host cells.
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spelling pubmed-70529312020-03-03 Epstein barr virus encodes miRNAs to assist host immune escape Li, Weiming He, Cong Wu, Jiayi Yang, Dazhi Yi, Weihong J Cancer Review Epstein-barr virus (EBV) is a definite tumorigenic virus, which can form life-long latency in the host, which is difficult to be recognized and completely eliminated by the immune system. It is closely related to the occurrence and development of nasopharyngeal cancer, gastric cancer and various types of lymphoma. At present, a total of 44 Epstein-barr virus-encoded microRNAs (EBV miRNAs) have been found. In response to the immune system of the body, EBV miRNAs can inhibit the expression and presentation of viral antigens, inhibit immune activation and immunotoxicity, assisting host cells to escape from immunity, and providing conditions for further immortalized tumorigenesis of the host cells. Ivyspring International Publisher 2020-02-03 /pmc/articles/PMC7052931/ /pubmed/32127936 http://dx.doi.org/10.7150/jca.42498 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Li, Weiming
He, Cong
Wu, Jiayi
Yang, Dazhi
Yi, Weihong
Epstein barr virus encodes miRNAs to assist host immune escape
title Epstein barr virus encodes miRNAs to assist host immune escape
title_full Epstein barr virus encodes miRNAs to assist host immune escape
title_fullStr Epstein barr virus encodes miRNAs to assist host immune escape
title_full_unstemmed Epstein barr virus encodes miRNAs to assist host immune escape
title_short Epstein barr virus encodes miRNAs to assist host immune escape
title_sort epstein barr virus encodes mirnas to assist host immune escape
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052931/
https://www.ncbi.nlm.nih.gov/pubmed/32127936
http://dx.doi.org/10.7150/jca.42498
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AT yangdazhi epsteinbarrvirusencodesmirnastoassisthostimmuneescape
AT yiweihong epsteinbarrvirusencodesmirnastoassisthostimmuneescape

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